Microwave-sensitive mPEG-PLGA Embolic Microspheres for Hepatocellular Carcinoma Therapy

doi:10.7517/j.issn.1674-0475.2018.02.002

Abstract

Abstract: In this paper, mPEG-PLGA microspheres with microwave sensitivity and good biosafety were prepared by double emulsion method for the treatment of hepatocellular carcinoma. The microspheres showed a uniform monodisperse with an average size of about 63 μm. Compared with saline, the microspheres coated with MoS₂ nanosheets dispersed in saline can be increased by 8.5℃ under microwave irradiation. For the subcutaneous H22 tumor of ICR mice, the ablation rate of tumor was 100% under microwave irradiation. For VX-2 liver orthotropic transplantation tumor in New Zealand white rabbits, the DSA images showed that the tumor and peripheral blood vessels disappeared rapidly after the hepatic arterial embolization, indicating the microspheres had a good embolization effect. 6 days after ablation, the necrosis diameters of the tumor in the two directions were 15.76 and 21.85 mm, respectively, compared with the microwave group (11.18 and 11.78 mm).

Key words: microwave sensitivity, mPEG-PLGA, hepatocellular carcinoma, embolization

TANG Shunsong, FU Changhui, HUANG Zhongbing, MENG Xianwei. Microwave-sensitive mPEG-PLGA Embolic Microspheres for Hepatocellular Carcinoma Therapy[J]. Imaging Science and Photochemistry, 2018, 36(2): 130-136.

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