Abstract: In this paper, we explored the clinical value of three-dimensional reconstruction based on Amira software in making the liver cancer surgery plan. In our retrospective study, 111 consecutive patients admitted for hepatectomy were included, among which 59 received preoperative CT (control group), and 52 received simultaneous three-dimensional reconstruction of liver and peripheral vessels (observation group). The scope of surgical resection, total volume of the liver and the volume of the pre-resection liver of the observation group were evaluated by two-dimensional and three-dimensional reconstruction. The differences among the clinical indicators of the two groups of patients were compared. The results showed that there was no significant difference in clinical characteristics between the two groups. The R0 resection rate was 88.5% in observation group, which was significantly higher than the control group (71.2%). In the observation group, there was no significant difference in the volume of liver resection 801 calculated by two different methods. There was no significant difference in actual postoperative liver resection volume between the observation group and the control group. The incidence of complications, intraoperative blood loss and time to block hilar vessels in the observation group were all lower than those in the control group. In a word, the three-dimensional reconstruction technology based on Amira software can help to find the critical relationship between the tumor and the vascular system, as well as the anatomical variation of the key parts of the operation, which can guide the individualized treatment, and improve the preoperative safety assessment.

Key words: Amira, three dimensional reconstruction technique, precise hepatectomy, hepatocellular carcinoma, portal vein