关键词: 乳腺癌根治术, 超声定位, 地佐辛, 右美托咪定, 竖脊肌阻滞, 恢复质量, 镇痛效果

Abstract: This paper investigated the value of ultrasound imaging techniques combined with dezocine and dexmedetomidine in radical mastectomy of breast cancer. 126 patients with radical breast cancer were selected as research subjects, and they were divided into two groups with 63 cases in each group using random number table method. Both the two groups were treated with erector spinae block by ultrasound imaging, 5 mg of dezocine was administered intravenously in the dezocine group, and in the combined group the dosage of dezocine was the same as that in the dezocine group, and then 0.5 μg/kg of dexmedetomidine was administered intravenously, followed by 0.3 μg/(kg·h) of dexmedetomidine pumped continuously. Cardiac monitors were applied to detect hemodynamic indexes, visual analog scoring (VAS) and Ramsay sedation scoring were used to evaluate the degree of analgesia and sedation, and enzyme-linked immunosorbent assay was used to determine the inflammatory stress indexes, while thequality of recovery and adverse effects were compared. The results showed the mean arterial pressure (MAP) and heart rate (HR) at T1, T2, T3 and T4 in the combined group were lower than those in the dezocine group, and the fluctuations were less than those in the dezocine group (P<0.05). The VAS and Ramsay scores at 3 h, 6 h, 12 h, 24 h and 48 h after surgery in the combined group were lower than those in the dezocine group (P<0.05). The serum tumor necrosis factor-alpha (TNA-α), interleukin-10 (IL-10) in the combined group was lower than those in the dezocine group at 3 d after surgery, while the expression of NK cells was higher than that in the dezocine group (P<0.05). The number of attempted compressions and effective compressions by the automatic intravenous analgesia pump (PCIA) in the combined group was less than that in the dezocine group at 48h after surgery (P<0.05). The comparison of the incidence of adverse reactions between the two groups, there was no statistically significant (P>0.05). Ultrasound imaging technology combined with dezocine and dexmedetomidine was applied to patients undergoing radical breast cancer surgery to achieve satisfactory sedative and analgesic effects, stabilize hemodynamics, improve the quality of early postoperative recovery, and have less effect on inflammatory stress with high safety.

Key words: radical mastectomy for breast cancer, ultrasound positioning, dezocine, dexmedetomidine, erector spinae block, restoration quality, analgesic effect