含有偶氮苯基的水溶性共聚物包覆的脂质体的光控释放行为

doi:10.7517/j.issn.1674-0475.1999.01.38

影像科学与光化学 ›› 1999, Vol. 17 ›› Issue (1): 38-44.DOI: 10.7517/j.issn.1674-0475.1999.01.38

含有偶氮苯基的水溶性共聚物包覆的脂质体的光控释放行为

史向阳¹, 孙曹民², 吴世康¹

1. 中国科学院感光化学研究所, 北京100101;
2. 北京理工大学生物材料实验室, 北京100081

收稿日期:1998-04-27 修回日期:1998-06-24 出版日期:1999-02-20 发布日期:1999-02-20
通讯作者: 吴世康
基金资助:
国家自然科学基金资助项目(批准号:29733100)

PHOTOCONTROLLED RELEASE BEHAVIOR OF LIPO SOMES COATED WITH A WATER SOLUBLE COPOLYMER CONTAINING AZOBENZENE GROUPS

SHI Xiangyang¹, SUN Caomin², WU Shikang¹

1. Institute of Photographic Chemistry, The Chinese Academy of Sciences, Beijing 100101, P. R. China;
2. Laboratory of Biomaterials, Beijing Institute of Technology, Beijing 100081, P. R. China

Received:1998-04-27 Revised:1998-06-24 Online:1999-02-20 Published:1999-02-20

摘要/Abstract

摘要： 为了研究侧链含有偶氮苯基的水溶性共聚物的光异构化对脂质体内包容物的光控释放的影响,设计合成了N-异丙基丙烯酰胺(NIPAM)和丙烯酰胺基偶氮苯(AAAB)的共聚物。以5(6)-羧基荧光素(5(6)-CF)为水溶性标记物,研究了共聚物包覆的小单层脂质体(small unilamellar vesicles,SUV)在室温25℃时的释放行为。研究发现,在波长大于350nm的光源照射下,共聚物包覆的脂质体中5(6)-CF的释放速率明显提高,证明侧链含有偶氮苯基的水溶性共聚物包覆的脂质体具有明显的光控释放性能。并对此现象作了讨论。

关键词: 水溶性高分子, 脂质体, 光控释放

Abstract: The copolymer of N-isopropylacrylamide (NIPAM) and acrylamido-azobenzene (AAAB) was synthesized for the study of the effect of the photoisomerization of a water soluble copolymer containing azobenzene groups on the photocontrolled release behavior of liposomes. The release property of small unilamellar vesicles(SUV) coated with the copolymer was studied at 25℃ by using 5(6)-carboxyfluorescein (5(6)-CF) as a water soluble marker. Results showed that under photoirradiation, the release of 5(6)-CF from liposomes coated with the copolymer containing azobenzene groups was remarkably increased and exhibits an obvious photocontrolled release property. This phenomenon was discussed preliminarily.

Key words: water soluble polymer, liposomes, photocontrolled release

史向阳, 孙曹民, 吴世康. 含有偶氮苯基的水溶性共聚物包覆的脂质体的光控释放行为[J]. 影像科学与光化学, 1999, 17(1): 38-44.

SHI Xiangyang, SUN Caomin, WU Shikang. PHOTOCONTROLLED RELEASE BEHAVIOR OF LIPO SOMES COATED WITH A WATER SOLUBLE COPOLYMER CONTAINING AZOBENZENE GROUPS[J]. Imaging Science and Photochemistry, 1999, 17(1): 38-44.

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含有偶氮苯基的水溶性共聚物包覆的脂质体的光控释放行为

PHOTOCONTROLLED RELEASE BEHAVIOR OF LIPO SOMES COATED WITH A WATER SOLUBLE COPOLYMER CONTAINING AZOBENZENE GROUPS

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