10-甲基吖啶苯酚酯衍生物的合成、表征及化学发光特性

doi:10.7517/j.issn.1674-0475.2008.04.257

影像科学与光化学 ›› 2008, Vol. 26 ›› Issue (4): 257-264.DOI: 10.7517/j.issn.1674-0475.2008.04.257

• 研究论文 • 下一篇

10-甲基吖啶苯酚酯衍生物的合成、表征及化学发光特性

穆小静¹, 刘敏², 严淑珊¹

1. 重庆大学, 化学化工学院, 重庆, 400030;
2. 华中科技大学, 同济医学院, 基础医学部, 湖北, 武汉, 430030

收稿日期:2007-11-09 修回日期:2008-03-10 出版日期:2008-07-23 发布日期:2008-07-23
通讯作者: 穆小静(1973-), 从事化学发光试剂及药物合成研究.
基金资助:
重庆市自然科学基金(CQCSTC2005BBS011).

Synthesis,Characterization and Chemiluminescence of 10-Methylacridinium Esters

MU Xiao-jing¹, LIU Min², YAN Shu-shan¹

1. College of Chemistry & Chemical Engineering, Chongqing University, Chongqing 400030, Sichuan, P.R.China;
2. Basic Medical College of Tongji Medicine College, Huazhong University of Science & Technology, Wuhan 430030, Hubei, P.R.China

Received:2007-11-09 Revised:2008-03-10 Online:2008-07-23 Published:2008-07-23

摘要/Abstract

摘要： 吖啶-9-羧酸苯酚酯是一类效率较高的化学发光试剂.其结构一般有两部分组成,吖啶环发光部分和9-羧酸苯酚酯离去基团.本文对离去基团进行修饰,分别在离去基团苯酚部分的2,5或2,6位引入取代基CF₃、NO₂、Br、CH₃,合成了4个新吖啶酯衍生物,并对它们的分子结构进行了表征.4个新化合物和模型化合物(无取代基)比较,均表现出较好的化学发光效率;发光动力学基本符合文献报道规律.而且化学发光法对其水解稳定性考察显示,取代基的电性和位阻是影响稳定性的两大因素.

关键词: 吖啶酯, 化学发光, 离去基团, 发光动力学, 化学发光量子产率

Abstract: The acridine esters are known chemiluminescent molecules with good quantum yield.As a chemiluminescnet regent,they are essentially composed of two parts:acridine ring and leaving group.Modifications on the leaving group have been made to yield four new derivatives with different substituents.And their molecular structures were characterized with ¹HNMR,¹³CNMR,IR and MS.All of them showed reasonable chemiluminescent kinetics and good quantum yields.The hydrolytic stability of the target compounds were tested by chemiluminescent method.

Key words: acridinium ester, leaving group, chemiluminescent kinetics, chemiluminescent quantum yield, hydrolytic stability

中图分类号:

穆小静, 刘敏, 严淑珊. 10-甲基吖啶苯酚酯衍生物的合成、表征及化学发光特性[J]. 影像科学与光化学, 2008, 26(4): 257-264.

MU Xiao-jing, LIU Min, YAN Shu-shan. Synthesis,Characterization and Chemiluminescence of 10-Methylacridinium Esters[J]. Imaging Science and Photochemistry, 2008, 26(4): 257-264.

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10-甲基吖啶苯酚酯衍生物的合成、表征及化学发光特性

Synthesis,Characterization and Chemiluminescence of 10-Methylacridinium Esters

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