含碘二氧化硅纳米颗粒对BODIPY染料光动力效果的影响

doi:10.7517/j.issn.1674-0475.2010.04.279

影像科学与光化学 ›› 2010, Vol. 28 ›› Issue (4): 279-286.DOI: 10.7517/j.issn.1674-0475.2010.04.279

含碘二氧化硅纳米颗粒对BODIPY染料光动力效果的影响

王建广^1,2, 李钊博^1,2, 侯原军¹, 张宝文¹, 王雪松¹

1. 中国科学院, 理化技术研究所, 北京, 100190;
2. 中国科学院, 研究生院, 北京, 100049

收稿日期:2010-04-14 修回日期:2010-05-06 出版日期:2010-07-23 发布日期:2010-07-23
通讯作者: 王雪松
基金资助:
国家自然科学基金资助项目(20772133,20873170)

Effects of Iodine-Containing SiO₂ Nanoparticles on the Photodynamic Activities of BODIPY Dye

WANG Jian-guang^1,2, LI Zhao-bo^1,2, HOU Yuan-jun¹, ZHANG Bao-wen¹, WANG Xue-song¹

1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R.China;
2. Graduate University of Chinese Academy of Sciences, Beijing 100049, P.R.China

Received:2010-04-14 Revised:2010-05-06 Online:2010-07-23 Published:2010-07-23

摘要/Abstract

摘要： 利用含碘硅烷前体制备包裹BODIPY染料分子的纳米二氧化硅颗粒.颗粒中的碘原子通过重原子效应有效提高了BODIPY染料分子的系间窜越效率,进而提高了染料分子的单重态氧量子产率及光损伤DNA的能力.这一结果表明,含碘二氧化硅纳米颗粒可以成为众多荧光染料分子在光动力疗法领域应用的一个有效药物负载和输送体系.

关键词: 光动力治疗, 重原子效应, 纳米颗粒, BODIPY染料

Abstract: Iodine-containing SiO₂ nanoparticles were prepared by using 3-iodopropyl-trimethoxysilane as precursor,in which a BODIPY fluorescence dye was encapsulated.The presence of iodine atoms renders the BODIPY dye higher intersystem crossing efficiency by way of heavy-atom effect,thus higher singlet oxygen efficiency and stronger DNA photocleavage capability,fully demonstrating the promising potential of iodine-containing SiO₂ nanoparticles as the effective nanocarrier for the photodynamic application of highly fluorescent dye molecules.

Key words: photodynamic therapy, heavy-atom effect, nanoparticle, BODIPY dye

中图分类号:

王建广, 李钊博, 侯原军, 张宝文, 王雪松. 含碘二氧化硅纳米颗粒对BODIPY染料光动力效果的影响[J]. 影像科学与光化学, 2010, 28(4): 279-286.

WANG Jian-guang, LI Zhao-bo, HOU Yuan-jun, ZHANG Bao-wen, WANG Xue-song. Effects of Iodine-Containing SiO₂ Nanoparticles on the Photodynamic Activities of BODIPY Dye[J]. Imaging Science and Photochemistry, 2010, 28(4): 279-286.

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含碘二氧化硅纳米颗粒对BODIPY染料光动力效果的影响

Effects of Iodine-Containing SiO₂ Nanoparticles on the Photodynamic Activities of BODIPY Dye

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含碘二氧化硅纳米颗粒对BODIPY染料光动力效果的影响

Effects of Iodine-Containing SiO2 Nanoparticles on the Photodynamic Activities of BODIPY Dye

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Effects of Iodine-Containing SiO₂ Nanoparticles on the Photodynamic Activities of BODIPY Dye