Abstract: In this paper, 100 patients with solitary pulmonary nodules (SPN) were selected to explore the efficacy of CT texture analysis and MSCT 3D reconstruction in the diagnosis of benign and malignant SPN. The texture feature parameters were extracted, and the ROC curve of the subject was established according to the data. Meanwhile, the MSCT 3D reconstruction was performed by volume display reconstruction method, and the efficacy of the two methods was explored based on the pathological results. The results showed that the entropy, the sum of entropy and the difference of entropy 914 in the malignant group were significantly higher than those in the benign group (P<0.05).ROC curve analysis showed that the accuracy of the three combined differential diagnosis of SPN was high, with sensitivity and specificity of 94.6% and 65.9%, respectively. The display rate of SPN morphological features of MSCT 3D reconstruction was significantly higher than that of CT plain scan (P<0.05).The sensitivity and specificity of MSCT 3D reconstruction were 88.9% and 82.6% respectively. It can be seen that both CT texture analysis and MSCT 3D reconstruction techniques are beneficial to the differential diagnosis of benign and malignant SPN. The former has a higher combined diagnosis sensitivity, while the latter has a higher specificity. Therefore, it is necessary to select the diagnosis method in combination with clinical science.

Key words: CT texture analysis, MSCT three-dimensional reconstruction, solitary pulmonary nodule, benign and malignant differentiation, diagnostic efficacy