Abstract: The purpose of this study was to explore the significance and value of high frequency ultrasound in the differential diagnosis of benign and malignant breast nodules. The general data of 122 patients with breast micronodules treated were analyzed retrospectively. All the patients were diagnosed by high frequency ultrasound. The blood flow status, blood flow parameters and two-dimensional sonographic features of benign and malignant nodules were analyzed. The diagnostic value of high frequency ultrasound was analyzed. The results showed that the proportion of grade Ⅰand grade Ⅲ of malignant nodules was lower than that of benign nodules (P<0.05), and the blood flow resistance index of malignant nodules was higher than that of benign nodules (P<0.05). The negative predictive value, sensitivity, positive predictive value, specificity and accuracy of high-frequency ultrasound in the diagnosis of malignant tiny breast nodules were 95.0%, 85.0%, 89.5%, 96.6% and 93.7%, respectively. There was no significant difference compared with pathological diagnosis (P>0.05). This study shows that high-frequency ultrasound can accurately diagnose benign and malignant breast small nodules by blood flow state and parameters, and has high accuracy and specificity. After using "BI-RADS" classification, the accuracy of high frequency ultrasound in the diagnosis of breast lesions has been significantly improved.

Key words: breast micronodules, benign and malignant diagnosis, high frequency ultrasound, accuracy, blood flow parameters, morphology