Rapid MRI Combined with Maternal Serum Markers in the Diagnosis of Fetal CNS Developmental Malformations in the Second Trimester of Pregnancy

doi:10.7517/issn.1674-0475.211143

Abstract

Abstract: This paper explored the application value of rapid MRI combined with maternal serum marker detection in the diagnosis of fetal central nervous system (CNS) developmental malformations in the second trimester of pregnancy. Selected 112 pregnant women with suspected fetuses CNS developmental malformations in the second trimester of pregnancy as research objects, and all of them underwent MRI examination and maternal serum marker detection. The results showed that the incidence of fetal CNS malformation was 18.75%; 19 cases of fetal CNS malformation were detected by rapid MRI, of which 18 were true positive. The serum levels of alpha-fetoprotein (AFP) and free β-human chorionic gonadotropin (Free-β-hCG) in the second trimester of mothers with fetal CNS malformation were higher than those of non-malformed mothers, while the levels of pregnancy-associated plasma protein-A (PAPP-A) and free estriol (uE3) were lower than those of non-malformed mothers (P<0.05). The levels of maternal serum AFP, Free-β-hCG, PAPP-A and uE3 were all independent influencing factors of fetal CNS malformation in the second trimester of pregnancy (P＜0.05). The area under the curve (AUC) for fetal CNS developmental malformations through rapid MRI combined with maternal serum AFP, Free-β-hCG, PAPP-A and uE3 diagnosis was 0.961. Rapid MRI combined with maternal serum marker detection has a high application value in the diagnosis of fetal CNS developmental malformations in the second trimester pregnancy.

Key words: fetal central nervous system developmental malformations, rapid MRI, alpha-fetoprotein, free estriol, pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin

SUN Lingling, HU Rong, HU Jingjing. Rapid MRI Combined with Maternal Serum Markers in the Diagnosis of Fetal CNS Developmental Malformations in the Second Trimester of Pregnancy[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(3): 659-664.

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