Abstract: This study investigated the value of clinical application of transcranial Doppler (TCD) to quantitatively evaluate the establishment of collateral circulation and neurological rehabilitation in patients with ischemic stroke caused by internal carotid artery (ICA) stenosis. 138 patients with ischemic stroke caused by unilateral ICA stenosis or occlusion diagnosed by digital silhouette angiography (DSA) were selected as research objects, and all patients underwent TCD examination. DSA was used as the gold standard to evaluate the value of TCD in diagnosing the establishment of collateral circulation in patients. The coincidence rates of TCD in diagnosing collateral circulation of anterior communicating artery, posterior communicating artery and ophthalmic artery with DSA were 91.53%, 90.91% and 86.05%, respectively. The diagnostic sensitivity and specificity of diagnosing collateral circulation in patients with ischemic stroke caused by unilateral ICA stenosis or occlusion were 89.88% and 90.65%. Among 138 patients with ischemic stroke caused by unilateral ICA stenosis or occlusion, including 60 patients with good collateral circulation and 78 patients with poor collateral circulation, the TCD quantitative score of the patients in the good group was significantly higher than that in the poor group (P<0.05). The brain CBF and CBV values were higher than those of the poor group (P<0.05), while the brain MTT and TTP values were lower than those of the unhealthy group (P<0.05). Clinically, TCD Diagnosis and quantitative evaluation of the establishment of collateral circulation in patients with ischemic stroke caused by ICA stenosis has a high accuracy, and the establishment of collateral circulation can be quantitatively evaluated by TCD to judge the degree of neurological deficit and recovery.

Key words: transcranial doppler, quantitative, internal carotid artery stenosis, ischemic brain, collateral circulation