Relationship between CTP Parameters and Cerebral Infarction Condition in Patients with Severe Stenosis or Occlusion of MCA

doi:10.7517/issn.1674-0475.220139

Abstract

Abstract: This study investigated the relationship between CT perfusion imaging (CTP) parameters and cerebral infarction and the establishment of collateral circulation in patients with severe middle cerebral artery (MCA) stenosis or occlusion. 143 patients with severe MCA stenosis or occlusive cerebral infarction were selected as the research subjects. Analyzed the patients' CTP parameters, including cerebral blood flow (CBF), time to peak (TTP), cerebral blood volume (CBV), mean transit time (MTT), according the size of the lesion, the location of the lesion, and the level of collateral circulation established in the patients with cerebral infarction. The relationship between CTP parameters and the National Institutes of Health Stroke Scale (NIHSS) score 24 hours after patients' admission were analyzed. Among the patients with severe MCA stenosis or occlusive cerebral infarction, the CBF value of patients with large-area cerebral infarction was lower than that of patients with moderate-area cerebral infarction, and the TTP value was higher than that of patients with moderate-area cerebral infarction (P<0.05). The CBF and CBV values of patients with collateral circulation grade 0 to 1 were lower than those of patients with collateral circulation grade 2 to 3, and the TTP value was higher than those of patients with collateral circulation grade 2 to 3 (P<0.05). The values of CBF, CBV and MTT in the core of cerebral infarction were lower than those in the penumbra area, and the value of TTP was higher than that in the penumbra area (P<0.05). The patient's NIHSS score was significantly negatively correlated with CBF (r=-0.664, P<0.000) and significantly positively correlated with TTP (r=0.690, P=0.000). There was no significant correlation between NIHSS score and CBV, MTT (P>0.05). CTP can better evaluate the size of infarct focus, the establishment of collateral circulation and the degree of neurological impairment in patients with severe stenosis or occlusion of MCA.

Key words: CT perfusion imaging, middle cerebral artery, severe stenosis, occlusion, cerebral infarction, collateral circulation

ZOU Shechang, LING Rong, ZHANG Zewei, WEN Yanbin, ZHENG Lifang. Relationship between CTP Parameters and Cerebral Infarction Condition in Patients with Severe Stenosis or Occlusion of MCA[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 741-745.

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