Application of CT Perfusion Imaging Combined with miR-195 in Diagnosis and Prognosis of Acute Cerebral Infarction

doi:10.7517/issn.1674-0475.220135

Abstract

Abstract: The purpose of this study was to explore the value of CT perfusion imaging (CTP) combined with microRNA-195 (miR-195) in the diagnosis and prognosis of acute cerebral infarction. 158 patients with acute cerebral infarction (the observation group) and 100 healthy people were selected (the control group). The serum miR-195 levels of patients in the two groups were detected by PCR, and the differences of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP) in the infarct area of different patients in the observation group were compared, at the same time the value of each parameter in predicting poor prognosis was analyzed. The level of serum miR-195 in the observation group was significantly higher than that in the control group (P<0.05). The CBF, CBV, MTT and TTP in the infarct area of patients with NIHSS score ≥ 5 and poor prognosis were significantly lower than those with NIHSS score <5 and good prognosis (P<0.05), while TTP and serum miR-195 relative expression was significantly higher than those with NIHSS score <5 and good prognosis (P<0.05). CBF, CBV and MTT were negatively correlated with NIHSS score (P<0.05), and the relative expression of TTP and serum miR-195 were positively correlated with NIHSS score (P<0.05). The areas under the ROC curve of CBF, CBV, MTT, TTP, miR-195 and combined prediction of poor prognosis of acute cerebral infarction were 0.685, 0.867, 0.630, 0.736, 0.669 and 0.936, respectively (P<0.05). CBF, CBV, MTT, TTP combined with miR-195 can predict the prognosis of patients with acute cerebral infarction effectively.

Key words: CT perfusion imaging, microRNA-195, acute cerebral infarction, prognosis

HAN Long, ZHANG Hailian, MA Qiong. Application of CT Perfusion Imaging Combined with miR-195 in Diagnosis and Prognosis of Acute Cerebral Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 927-931.

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