Application of Echocardiography Combined with Serum miR-26b-5p in the Diagnosis of Acute Myocardial Infarction

doi:10.7517/issn.1674-0475.220321

Abstract

Abstract: This paper discussed the diagnostic value of echocardiography combined with serum microRNA-26b-5p (miR-26b-5p) in acute myocardial infarction (AMI). 115 patients with AMI (observation group) and 80 patients with old myocardial infarction were selected as the control group, the echocardiographic parameters and serum miR-26b-5p of the two groups were analyzed. The left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVEDs), left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV) and myocardial work index (Tei) in the observation group were higher than those in the control group (P<0.05), while the left ventricular ejection fraction (LVEF), E/A and miR-26b-5p were significantly lower than those in the control group (P<0.05). There were significant differences in LVEF and serum miR-26b-5p levels in patients with different degrees of coronary stenosis (P<0.05). The serum miR-26b-5p was negatively correlated with Gensini score (r=-0.503, P<0.05). The sensitivity and negative predictive value of echocardiography combined with serum miR-26b-5p in the diagnosis of AMI were significantly higher than that of echocardiography alone (P<0.05). Follow-up results showed that LVEDs and LVESV in patients with major adverse cardiovascular events (MACE) were significantly higher than those without MACE (P<0.05), and LVEF and miR-26b-5p were significantly lower than those without MACE (P<0.05). The areas under the ROC curve of LVEDs, LVEF, miR-26b-5p and combined prediction of MACE were 0.753, 0.732, 0.701 and 0.915, respectively, P<0.05. The serum level of miR-26b-5p is decreased in patients with acute myocardial infarction, miR-26b-5p combined with echocardiographic parameters has a good application value in differential diagnosis of AMI and prediction of MACE.

Key words: echocardiography, microRNA-26b-5p (miR-26b-5p), acute myocardial infarction, prognosis, diagnostic value

QIN Jizhou, JIN Yan, LUO Zhaojun. Application of Echocardiography Combined with Serum miR-26b-5p in the Diagnosis of Acute Myocardial Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1083-1087.

References

[1] 谭国娟, 刘宏斌, 刘宏伟, 等. 急诊床旁超声心动图诊断老年急性心肌梗死并发特殊类型的心脏破裂病例分析[J]. 中华老年心脑血管病杂志, 2020, 22(8):832-835.
[2] Chen Y Q, Li S, Zhang Y, et al. The lncRNA malat1 regulates microvascular function after myocardial infarction in mice via miR-26b-5p/Mfn1 axis-mediated mitochondrial dynamics[J]. Redox Biology, 2021, 41(10):101910.
[3] 李胜, 郑光美. 斑点追踪超声心动图对急性心肌梗死PCI术后左心室重构的评价作用研究[J]. 影像科学与光化学, 2020, 38(4):626-631.
[4] Jung S E, Kim S W, Jeong S, et al. microRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a[J]. Experimental & Molecular Medicine, 2021, 53(9):1332-1343.
[5] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会, 《中国循环杂志》编辑委员会. 急性心肌梗死诊断和治疗指南[J]. 中华心血管病杂志, 2001, 29(12):710-725.
[6] Gensini G G.A more meaningful scoring system for determining the severity of coronary heart disease[J]. The American Journal of Cardiology, 1983, 51(3):606.
[7] Luo Y D, Ji H, Cao Y, et al. miR-26b-5p/TCF-4 controls the adipogenic differentiation of human adipose-derived mesenchymal stem cells[J]. Cell Transplantation, 2020, 29(9):963689720934418.
[8] Li H, Xu J D, Fang X H, et al. Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4[J]. Cardiovascular Research, 2019, 116(7):1323-1334.
[9] 周璇奕, 周前波, 白建宁, 等. 实时三维超声心动图定量评价心肌梗死患者经皮冠状动脉介入治疗前后左室收缩功能的研究[J]. 临床超声医学杂志, 2019, 21(6):418-421.
[10] 蔡思, 孙效容, 赵淑珍, 等. 正常与缺血性心肌梗死及心肌肥厚大鼠超声心动图参数变化趋势比较[J]. 西部医学, 2019, 31(4):508-512.
[11] Lian Y F, Jiang D X, Sun J T. Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A[J]. Cellular & Molecular Biology Letters, 2021, 26(1):24.
[12] 贺凌婕, 张建维, 刘晋星. miR-26b调控Sox6和Bhlhe22基因表达影响胰岛素分泌的机制研究[J]. 临床和实验医学杂志, 2020, 19(22):2393-2396.
[13] 娜日松, 孙亮, 赵振群, 等. miR-26b调控脂肪酸结合蛋白4介导脂肪细胞分化的分子机制[J]. 中国组织工程研究, 2022, 26(2):260-265.
[14] 徐广峰, 付海龙, 史春梅, 等. 生物信息学预测hsa-miR-26b的作用靶标及功能[J]. 临床检验杂志, 2012, 30(7):527-530.

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