Correlation between the Dynamic Contrast-Enhanced MRI Time-signal Intensity Curve and the Biological Behavior of Tumor Cells in Breast Cancer Patients
- YE Dongliang, CHENG Shide, FAN Gaojie, ZHENG Xiaomei
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This study explored the correlation between the dynamic enhanced MRI time-signal intensity curve and the biological behavior of tumor cells in breast cancer patients. 60 patients with breast cancer were selected as the observation group, and 60 patients admitted to the same period with benign breast lesions were selected as the control group. All patients underwent dynamic enhanced MRI examination. The results showed that the maximum concentration of contrast agent (Max Cone), area under time-signal intensity curve (AUC), time-signal intensity curve maximum slope (Max Slop), rate constant (Kep), transport constant (Ktrans), plasma volume fraction (Vp) in the observation group were higher than those in the control group, while the time to peak (TTP) was lower than that in the control group (P<0.05). The AUC of Ktrans, Kep, Vp, TTP, Max Cone, Max Slop and (time-signal intensity curve) AUC in the combined diagnosis of breast cancer were 0.913. The mRNA expression levels of CXCL1, Notch1, Gab2 and FOXF1 in observation group were higher than those in the control group, while the expressions of ATG2B and ATG4D were lower than the control group (P<0.05). The dynamic contrast-enhanced MRI time-signal intensity curve parameters of Ktrans, Kep, Vp, Max Cone, Max Slop, AUC was positively correlated with the mRNA expression of CXCL1, Notch1, Gab2, FOXF1, while negatively correlated with ATG2B, ATG4D mRNA expression (P<0.05). TTP was negatively correlated with CXCL1, Notch1, Gab2, FOXF1 mRNA expression, and was positively correlated with ATG2B, ATG4D mRNA expression (P<0.05). The parameter changes of dynamic enhanced MRI time-signal intensity curve in breast cancer patients are closely related to the biological behavior of tumor cells.