Correlation Analysis of Ultrasound SWV Value, Serum APRI and the Degree of Liver Fibrosis in Children with Biliary Atresia

doi:10.7517/issn.1674-0475.220521

Abstract

Abstract: This study investigated the clinical value of liver shear wave velocity (SWV) and serum aspartate aminotransferase (AST) to platelet ratio index (APRI) in the diagnosis of liver fibrosis in children with biliary atresia (BA). 102 children with BA were selected as the BA group, and 50 healthy infants of the same age were selected as the control group. Both groups received ultrasound examination and laboratory index detection, and they were grouped and compared according to the degree of liver fibrosis. The value of SWV and APRI values in diagnosing BA was analyzed, and the relationship between SWV and APRI values and liver fibrosis indexes was analyzed. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), direct bilirubin (DBIL) and APRI indexes of the children in the BA group were higher than those in the control group. The platelet (PLT) value of the children in the BA group was lower than that in the control group (P<0.05). The measured values of laminin (LN), hyaluronic acid (HA), type Ⅲ procollagen (PCⅢ) and type Ⅳ collagen (Ⅳ-Col) in the BA group were higher than those in the control group (P<0.05). The liver fibrosis score and SWV value of the children in the BA group were higher than those of the control group (P<0.05). The SWV value of children in BA group was positively correlated with LN, HA, PCⅢ, Ⅳ-Col and liver fibrosis score (P<0.05). APRI value was positively correlated with liver fibrosis score (P<0.05). The SWV value and APRI value of children in BA group with fibrosis grade ≥ F2 were higher than those of children with P<0.05). The AUC values of SWV value and APRI value in differential diagnosis of obvious liver fibrosis in children with BA were 0.980 and 0.858 respectively. SWV value and APRI value have certain value in diagnosing liver fibrosis and the severity of fibrosis in children with BA, and are correlated with liver fibrosis indicators.

Key words: hepatic shear wave velocity, aspartate aminotransferase, platelets, biliary atresia, liver fibrosis, jaundice

ZHANG Jieyuan, PU Siyu. Correlation Analysis of Ultrasound SWV Value, Serum APRI and the Degree of Liver Fibrosis in Children with Biliary Atresia[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1200-1204.

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