Value Analysis of Ultrasound Combined with VEGFA in Diagnosis of Biliary Atresia

doi:10.7517/issn.1674-0475.220504

Abstract

Abstract: In order to investigate the value of ultrasound combined with vascular endothelial growth factor A (VEGFA) in the diagnosis of biliary atresia (BA), this study examined 108 patients with cholestasis suspected of BA by ultrasonography, and obtained the long diameter of the gallbladder, the thickness of the hilar fibrous mass and the liver stiffness. Serum VEGFA of patients with cholestasis and healthy subjects was detected by ELISA. The results showed that the long diameter of gallbladder in BA patients was lower than that in non-BA patients, while the thickness of hepatic hilar fibrous mass and liver stiffness were higher than those in non-BA patients (P<0.001). Serum VEGFA levels in BA and non-BA patients were higher than those in healthy people, while BA patients had higher serum VEGFA levels than non-BA patients (P<0.001). The combined AUC (0.948) and specificity (98.25%) of the three ultrasound parameters for the diagnosis of BA were higher than those for the diagnosis alone. The AUC, sensitivity and specificity of serum VEGFA for diagnosing BA were 0.850, 78.43% and 77.19%,respectively. The AUC, sensitivity and specificity of ultrasound parameters combined with serum VEGFA in the diagnosis of BA were 0.978, 98.04% and 89.47%,respectively. The sensitivity of ultrasound parameters combined with serum VEGFA in the diagnosis of BA are higher than those of single diagnosis and combined diagnosis of ultrasound parameters, and the specificity is second only to the combined diagnosis of ultrasound parameters. This diagnostic method has high clinical application value.

Key words: ultrasound, biliary atresia, vascular endothelial growth factor A, long diameter of gallbladder, hepatic hilar fibrous mass thickness, liver stiffness value

WU Jingjing, QIN Xin, CHEN Die, HAN Xiao, ZHAO Yanyan, ZHANG Boyang, QIN Wen. Value Analysis of Ultrasound Combined with VEGFA in Diagnosis of Biliary Atresia[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1045-1050.

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