Application of HR-HPV Gene Combined with TV-CDFI in Cervical Cancer Screening and Diagnosis

doi:10.7517/issn.1674-0475.220603

Abstract

Abstract: This study investigated the application value of high-risk human papillomavirus (HR-HPV) genetic testing combined with transvaginal color Doppler ultrasonography (TV-CDFI) in cervical cancer screening and diagnosis. 84 patients with cervical cancer (cervical cancer group), 100 patients with cervical epithelial neoplasia (CIN group), and 100 patients with cervicitis (inflammatory group) were selected. Three groups of patients were detected by HPV E6/E7 mRNA detection method and second-generation hybrid capture technology (HC2) method to detect the positive rate of HPV infection in cervical tissue, and pathological results were regarded as the gold standard to analyze the two methods to differentially diagnose cervical cancer and cervical epithelial tumor changing value. Detected the cervical cancer adler grade by TV-CDFI. The results showed that the sensitivity and specificity of HPV E6/E7 mRNA detection in the differential diagnosis of cervical cancer and CIN patients were 95.24% and 20.00%, respectively. The sensitivity and specificity of HC2 method in the differential diagnosis of cervical cancer and CIN patients were 97.62% and 17.00%, respectively. The sensitivity and specificity of HPV E6/E7 mRNA detection in the differential diagnosis of cervical cancer and cervicitis were 95.24% and 89.00%. The sensitivity and specificity of HC2 method in the differential diagnosis of cervical cancer and cervicitis were 97.62% and 92.00%. HPV E6/E7 mRNA detection method and HC2 method have high clinical value in the differential diagnosis of cervicitis and cervical cancer. TV-CDFI detection of cervical cancer Adler grading is closely related to disease progression, therefore, the combination of HR-HPV detection and TV-CDFI in cervical cancer screening has high clinical value.

Key words: high-risk human papillomavirus, transvaginal color Doppler ultrasound, cervical cancer, screening, diagnosis

CHENG Mingyan, JIANG Hao, SUN Yanan, WANG Yanchun, YANG Tao, MEI Yanfang, DU Jianwen, WANG Jinghua. Application of HR-HPV Gene Combined with TV-CDFI in Cervical Cancer Screening and Diagnosis[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1481-1485.

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