IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1010-1014.DOI: 10.7517/issn.1674-0475.220404

• Review and Articles • Previous Articles     Next Articles

Research Progress in the Application of Ultrasound-targeted Microbubble Destruction Technology in Myocardial Infarction

LU Xiangxiang1,2, LIU Yan2, HUANG Zhaohe1   

  1. 1. Graduate School of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, P. R. China;
    2. Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, P. R. China
  • Received:2022-04-26 Published:2022-09-13

Abstract: Ultrasound-targeted microbubble destruction (UTMD) technology is a novel physical property-targeted gene delivery system, which is a hot research field in the treatment of myocardial infarction. This review introduced the structure, function and development of microbubbles, and discussed the application principle of UTMD technology and the application status of UTMD technology in myocardial infarction. The possible mechanisms of UTMD in the treatment of myocardial infarction were analyzed from the perspectives of promoting angiogenesis, promoting homing of transplanted cells, promoting the regeneration of infarcted myocardium, reducing myocardial cell apoptosis, inhibiting oxidative stress and improving myocardial microenvironment. On this basis, the advantages and disadvantages of UTMD technology were discussed. This review will summarize the research status of UTMD technology, so as to provide theoretical support for the later research and development of this technology.

Key words: ultrasound, microbubble, ultrasound-targeted microbubble destruction technology, myocardial infarction, myocardial ischemia-reperfusion