The Relationship between Mean SWV and MGMT and Prognosis of Breast Invasive Ductal Carcinoma

doi:10.7517/issn.1674-0475.220726

Abstract

Abstract: The relationship between the mean shear wave velocity (SWV) and the expression of O⁶ methylguanine DNA methyltransferase (MGMT) in female invasive ductal carcinoma and the prognosis of patients was investigated. 90 patients with breast invasive ductal carcinoma were selected as the observation group, 90 patients with benign breast lesions were selected as the control group. The SWV value of the two groups of patients was detected by color ultrasonography, and the expression of MGMT in the tumor tissue was detected by immunohistochemical method. The relationship between the mean value of SWV, the positive expression of MGMT and the clinicopathological characteristics of the observation group was analyzed. The average value of SWV and the positive expression rate of MGMT in the observation group were significantly higher than those in the control group (P<0.05). The mean value of SWV was related to lesion diameter, degree of differentiation, TNM stage and lymph node metastasis (P<0.05). The positive expression rate of MGMT in estrogen receptor (ER)-negative patients in the observation group was significantly higher than that in ER-positive patients (P<0.05). The progression free survival time of patients with SWV≥5.60 m/s was significantly shorter than that of patients with SWV<5.60 m/s (P<0.05). There was no significant relationship between MGMT expression and progression free survival time (P>0.05). The mean value of SWV and the expression of MGMT in female invasive ductal carcinoma are related to clinicopathological features, the mean value of SWV is related to the prognosis of patients, while MGMT is not significantly related to the prognosis.

Key words: invasive ductal carcinoma of breast, shear wave velocity, O6 methylguanine DNA methyltransferase, prognosis

LIU Zhiwei, LIU Qing, HU Maofei, WEN Wei. The Relationship between Mean SWV and MGMT and Prognosis of Breast Invasive Ductal Carcinoma[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1560-1564.

References

[1] 陈媛娴, 王兴田, 刘洁, 等. 声触诊组织成像定量技术所测剪切波速度与乳腺癌病理分级及分型的关系[J]. 中国医学影像技术, 2021, 37(6):895-898.
[2] 秦菁, 孝梦甦, 朱庆莉. 影像学在老年女性乳腺癌诊治中的应用进展[J]. 中国医学科学院学报, 2022, 44(3):478-483.
[3] 胡丹婷, 郑晓静, 尤超, 等. 数字乳腺摄影联合超声在小乳腺癌诊断中的应用[J]. 中国超声医学杂志, 2022, 38(3):267-270.
[4] 刘瑜. 高频彩色多普勒超声检查在乳腺癌患者诊断中的应用价值[J]. 医学临床研究, 2019, 36(2):324-326.
[5] 崔灵芝, 章扬培, 宋三泰. MGMT与恶性肿瘤[J]. 军事医学科学院院刊, 2004, 28(4):385-387.
[6] 余畅月, 张雷光, 高国峰. 超声剪切波弹性模量与乳腺病灶良恶性及乳腺癌分子亚型的相关性[J]. 实用癌症杂志, 2022, 37(5):826-829.
[7] 梁铭, 欧冰, 吴嘉仪, 等. 剪切波弹性成像和应变弹性成像对乳腺癌诊断价值的研究[J]. 中国超声医学杂志, 2019, 35(4):310-312.
[8] Bouvier A S, Panchbhaya N, Brochard C, et al. Uterine metastasis from invasive ductal breast carcinoma:A case report with literature review[J]. Journal of Gynecology Obstetrics and Human Reproduction, 2021, 50(1):101993.
[9] Taware R, More T H, Bagadi M, et al. Lipidomics investigations into the tissue phospholipidomic landscape of invasive ductal carcinoma of the breast[J]. RSC Advances, 2020, 11(1):397-407.
[10] 王晓宇, 赵治宇, 曹新宇, 等. 声触诊组织成像定量对浸润性导管癌Her-2表达的预测价值[J]. 中国超声医学杂志, 2021, 37(10):1102-1105.
[11] 倪茗, 刘婷婷, 汪俊, 等. 死亡相关蛋白激酶1、KLF4、6-氧-甲基鸟嘌呤-DNA甲基转移酶甲基化状态检测及与宫颈癌人乳头瘤病毒16感染的关系[J]. 实用临床医药杂志, 2022, 26(8):117-121.
[12] 张天华, 邹小明, 刘建丰, 等. MGMT蛋白在胃癌中的表达及其临床意义[J]. 中国普通外科杂志, 2005, 14(3):225-227.
[13] 陆欢, 陈莹蓉, 孙立奇, 等. 宫颈癌及宫颈上皮内瘤变MGMT基因甲基化及其相关性研究[J]. 浙江医学, 2014, 36(22):1841-1843.
[14] 简生燕, 徐燕, 刘寿, 等. DNA修复因子MGMT甲基化与子宫颈癌的相关性研究[J]. 青海医学院学报, 2012, 33(2):90-94.
[15] 高艳萍, 王泽华, 李敏, 等. 宫颈癌组织中DNA修复基因O⁶-甲基鸟嘌呤-DNA甲基转移酶启动子区过甲基化研究[J]. 现代妇产科进展, 2007, 16(8):569-572.