IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (6): 1560-1564.DOI: 10.7517/issn.1674-0475.220726

• Review and Articles • Previous Articles     Next Articles

The Relationship between Mean SWV and MGMT and Prognosis of Breast Invasive Ductal Carcinoma

LIU Zhiwei, LIU Qing, HU Maofei, WEN Wei   

  1. General Surgery Department, Hainan Hospital of Chinese PLA General Hospital, Sanya 572013, Hainan, P. R. China
  • Received:2022-07-18 Online:2022-11-23 Published:2022-11-15

Abstract: The relationship between the mean shear wave velocity (SWV) and the expression of O6 methylguanine DNA methyltransferase (MGMT) in female invasive ductal carcinoma and the prognosis of patients was investigated. 90 patients with breast invasive ductal carcinoma were selected as the observation group, 90 patients with benign breast lesions were selected as the control group. The SWV value of the two groups of patients was detected by color ultrasonography, and the expression of MGMT in the tumor tissue was detected by immunohistochemical method. The relationship between the mean value of SWV, the positive expression of MGMT and the clinicopathological characteristics of the observation group was analyzed. The average value of SWV and the positive expression rate of MGMT in the observation group were significantly higher than those in the control group (P<0.05). The mean value of SWV was related to lesion diameter, degree of differentiation, TNM stage and lymph node metastasis (P<0.05). The positive expression rate of MGMT in estrogen receptor (ER)-negative patients in the observation group was significantly higher than that in ER-positive patients (P<0.05). The progression free survival time of patients with SWV≥5.60 m/s was significantly shorter than that of patients with SWV<5.60 m/s (P<0.05). There was no significant relationship between MGMT expression and progression free survival time (P>0.05). The mean value of SWV and the expression of MGMT in female invasive ductal carcinoma are related to clinicopathological features, the mean value of SWV is related to the prognosis of patients, while MGMT is not significantly related to the prognosis.

Key words: invasive ductal carcinoma of breast, shear wave velocity, O6 methylguanine DNA methyltransferase, prognosis