Abstract: This study investigated the application value of quantitative parameters of carotid ultrasound combined with microRNA 128-3p (miR-128-3p) in the diagnosis and prognosis prediction of acute cerebral infarction(ACI). 120 patients with ACI were selected as the observation group, and 100 healthy volunteers matched for age and gender were selected as the control group. The levels of miR-128-3p in peripheral blood of the two groups were detected by RT-qPCR, and carotid ultrasound examination was performed in the observation group. At the same time, the quantitative parameters of carotid ultrasound and the level of miR-128-3p difference were compared between patients with different neurological impairment and patients with different prognosis in the observation group. The relative expression of miR-128-3p in peripheral blood of the observation group was higher than that of the control group (P<0.05). The peak systolic velocity (PSV) of patients with severe impairment was significantly lower than that of patients with mild and moderate impairment (P<0.05), while the relative expression levels of end diastolic blood flow velocity (EDV), carotid intima-media thickness (IMT) and miR-128-3p were significantly higher than those of patients with mild and moderate impairment (P<0.05). The PSV of patients with poor prognosis was lower than that of patients with good prognosis (P<0.05), while the relative expression levels of EDV, IMT and miR-128-3p were higher than those of patients with good prognosis (P<0.05). The area under the ROC curve of carotid ultrasound quantitative parameters combined with miR-128-3p for predicting poor prognosis of acute cerebral infarction was 0.986, which was higher than that predicted by each index alone (P<0.05). PSV, EDV, IMT and the relative expression of miR-128-3p were related to the degree of neurological impairment and prognosis of patients. Quantitative parameters of carotid ultrasound combined with miR-128-3p have a certain application value in predicting the prognosis of patients.

Key words: carotid ultrasound, microRNA 128-3p, acute cerebral infarction, prognosis