The Influence of PEG Grafting Level on the Drug Loading Capacity and Stability of Gold Nanoshells on Silica Nanorattles

doi:10.7517/j.issn.1674-0475.2011.03.212

Abstract

Abstract: In this paper,we grafted various amounts of polyethylene glycol(PEG) onto the surface of gold nanoshells on silica nanorattles(GSNs) and investigated the effects of grafting level about drug loading capacity and stability of GSNs.The results showed that the average thickness of GSNs increased about 4 nm after PEGylation.With the increase of PEGylation,the sedimentation rate of GSNs decreased gradually and the stability increased,and GSNs keeps good stability after standing 35 days.Inductively coupled plasma atomic emission spectrometry(ICP-OES) tests show that it will reach saturation point of PEGylation when the molar ratio of PEG and Au reaches nearly 0.24.In addition,it has no influence on drug loading capacity about different PEGylation processes.The results of this study will provide an important theoretical basis for the optimization the PEGlyation on the surface of inorganic nanomaterials and for the development of inorganic nano-carrier materials in vivo applications.

Key words: polyethylene glycol, gold nanoshells on silica nanorattles, stability, drug loading capacity

CLC Number:

CHEN Shuai-na, LIU Hui-yu, CHEN Dong, WU Xiao-li, TANG Fang-qiong, YANG Wen-zhi. The Influence of PEG Grafting Level on the Drug Loading Capacity and Stability of Gold Nanoshells on Silica Nanorattles[J]. Imaging Science and Photochemistry, 2011, 29(3): 212-221.

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