Diagnostic Value of 18F-FDG PET/CT Imaging Combined with Tumor Markers in Unexplained Peritoneal Effusion in Women

doi:10.7517/issn.1674-0475.190819

Abstract

Abstract: The aim of this paper is to investigate the value of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) combined with tumor markers in diagnosis of unexplained peritoneal effusion in women. The ¹⁸F-FDG PET/CT imaging data and tumor markers of 95 women with unexplained peritoneal effusion were retrospectively analyzed and compared with the pathological diagnosis. In the 95 patients, 74 patients were malignant and 21 patients were benign. The diagnostic sensitivity, specificity and accuracy of PET/CT for benign and malignant ascites were 98.65%, 19.05% and 81.05%, respectively. The SUV_max of malignant peritoneal effusion was significantly higher than that of benign peritoneal effusion (P>0.05). The patients were further subdivided according to the etiology, SUV_max in ovarian cancer group was significantly higher than that in group of other benign causes (P<0.05), but there was no significant difference between the ovarian cancer group, the tuberculosis group and other malignant tumors group (P>0.05). CA125 was the most effective marker for the diagnosis of ovarian cancer and tuberculosis-induced peritoneal effusion. The sensitivity, specificity and accuracy of CA125 were 98.2%, 7.7% and 81.4%, respectively. There was no significant difference between the diagnosis of CA125 or PET/CT alone and the combined diagnosis of them (P>0.05). The research shows that ¹⁸F-FDG PET/CT has high sensitivity and accuracy in the diagnosis of unexplained peritoneal effusion in women, but its specificity is poor. Combined examination of tumor markers can not improve the diagnosis of ascites caused by ovarian cancer and tuberculosis.

Key words: unexplained peritoneal effusion, ¹⁸F-fluorodeoxyglucose, positron emission tomography/computed tomography, tumor markers

CLC Number:

XIE Ran, YANG Qingxiong. Diagnostic Value of ¹⁸F-FDG PET/CT Imaging Combined with Tumor Markers in Unexplained Peritoneal Effusion in Women[J]. Imaging Science and Photochemistry, 2020, 38(2): 218-224.

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Diagnostic Value of ¹⁸F-FDG PET/CT Imaging Combined with Tumor Markers in Unexplained Peritoneal Effusion in Women

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