Abstract: This study explored the correlation between MRI and high-sensitivity C-reactive protein (hs-CRP), high mobility group protein B1 (HMGB1) and its diagnostic value in patients with cerebral infarction. 120 patients with suspected cerebral infarction were selected. 70 patients with finally diagnosed cerebral infarction were selected as the observation group, and the other 50 as the control group. MRI was performed to observe lumen area (LA), total vessel area (TVA) and tube wall area (WA). hs-CRP was detected by immunorate nephelometry, and HMGB1 was detected by enzyme-linked immunosorbent assay (ELISA). The results showed that compared with the control group, the levels of LA and TVA were lower in the study group, and the levels of WA, hs-CRP and HMGB1 were higher (P<0.05). LA and TVA were both negatively correlated with hs-CRP, HMGB1 and the degree of disease (P<0.05), while WA was positively correlated with hs-CRP, HMGB1 and the degree of disease (P<0.05). The AUC of LA combined with WA, TVA in the diagnosis of cerebral infarction was 0.839 (P<0.05). MRI has a certain correlation with hs-CRP, HMGB1 and the severity of the disease and has a diagnostic value for cerebral infarction.

Key words: magnetic resonance imaging, hypersensitive C-reactive protein, high-mobility family protein B1, cerebral infarction