IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (6): 1507-1512.DOI: 10.7517/issn.1674-0475.220827

• Review and Articles • Previous Articles     Next Articles

Changes and Clinical Significance of aEEG, MRI, Serum MMP and TIMP in Neonates with Intracranial Hemorrhage

YAN Yonglei1, LI Wen1, LUO Bin2, TANG Jing1, REN Xinyue1, FU Tianli1, ZHAO Jing1, YIN Meile1, CHEN Liqi1   

  1. 1. Chengde Central Hospital, Chengde 067000, Hebei, P. R. China;
    2. Huizhou Second Maternal and Child Health Hospital(Women and Children's Hospital Affiliated to Guangdong Medical University), Huizhou 516000, Guangdong, P. R. China
  • Received:2022-08-15 Online:2022-11-23 Published:2022-11-15

Abstract: This study investigated the characteristic changes of amplitude-integrated electroencephalography (aEEG), magnetic resonance imaging (MRI) and serum levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) in neonates with intracranial hemorrhage, and its meaning. A total of 63 neonates with confirmed intracranial hemorrhage were selected as the hemorrhage group, and 80 healthy neonates during the same period were selected as the control group. In 63 neonates with intracranial hemorrhage, the detection rate of contralateral ventricular hemorrhage by SWI (50.79%) was higher than that of conventional MRI sequence (33.33%) (P<0.05). The proportion of children with continuous background activity in the continuous voltage and the proportion of children with sleep-wake cycles in the bleeding group were lower than those in the control group (P<0.05). The measured values of the lower boundary voltage of the QS phase and the lower boundary voltage of the AS phase of the children in the hemorrhage group were lower than those of the control group, and the measured values of the QS phase bandwidth and the AS phase bandwidth of the children in the hemorrhage group were higher than those of the control group (P<0.05). The serum levels of MMP-9 and TIMP-1 in the hemorrhage group were significantly higher than those in the control group (P<0.05). The serum levels of MMP-9 and TIMP-1 in the mall bleeding volume group, the medium bleeding volume group, and the large bleeding volume group gradually increased (P<0.05),and the difference between the two groups was statistically significant (P<0.05). SWI examination in neonates with intracranial hemorrhage can more accurately assess the bleeding site. aEEG has high diagnostic value for intracranial hemorrhage. Serum MMP-9 and TIMP-1 are related to the amount of intracranial hemorrhage. Comprehensive analysis of MRI, aEEG and serum MMP-9 and TIMP-1 levels is conducive to better clinical diagnosis of neonatal intracranial hemorrhage.

Key words: intracranial hemorrhage, amplitude-integrated EEG, magnetic resonance imaging, matrix metalloproteinase 9, tissue inhibitor of metalloproteinase