Abstract: This paper explored the diagnostic value of cerebrospinal fluid CD64 and serum inflammatory factor levels combined with enhanced MRI in postoperative secondary nervous system infection. Selected 75 patients with meningitis after neurosurgery, and compared the levels of cerebrospinal fluid CD64, serum procalcitonin (PCT), C-reactive protein (CRP) and the differences of MRI signs between bacterial meningitis and aseptic meningitis patients. The area under the ROC curve(AUC) of cerebrospinal fluid CD64, serum PCT and CRP in differential diagnosis of bacterial meningitis were 0.949, 0.925 and 0.874, respectively. The MRI signs of bacterial meningitis and aseptic meningitis were different (P<0.05). Compared with MRI enhanced scan alone, the sensitivity of cerebrospinal fluid CD64, serum PCT, CRP combined with enhanced scan in the diagnosis of bacterial meningitis was improved, but there were no statistically significant difference (P>0.05). Cerebrospinal fluid CD64, serum PCT and CRP combined with MRI enhanced scanning have certain application value in the differential diagnosis of postoperative secondary nervous system infection, which is worthy for further study.

Key words: cerebrospinal fluid, CD64, serum, magnetic resonance imaging, bacterial meningitis, aseptic meningitis