Characteristics Analysis of MRI in the Diagnosis of Invasive Pituitary Adenomas and Effect Observation of the Surgical Effect of Endoscopic Double Nostril Approach

doi:10.7517/issn.1674-0475.221014

Abstract

Abstract: This study investigated the magnetic resonance imaging (MRI) features of invasive pituitary adenomas and the clinical effects of endoscopic bilateral nostril approach. 35 patients with invasive pituitary adenoma were selected as the invasive group, and 25 patients in the same period with non-invasive pituitary adenoma were selected as the non-invasive group. The differences of MRI imaging parameters between the two groups were compared. Both groups were treated by endoscopic double-nostril approach, and the surgical effect and changes of serum growth hormone and prolactin levels of patients were observed. The invasive group was mainly characterized by large adenoma and giant adenoma, while the non-invasive group was mainly characterized by microadenoma (P<0.05). There was no significant difference in the composition of prolactin (PRL) adenoma, adrenocorticotropic hormone (ACTH) adenoma, growth hormone (GH) adenoma, mixed adenoma and non-functional pituitary adenoma between the invasive group and the non-invasive group (P>0.05). Patients in the invasion group mainly showed slow rising time-signal intensity curve and plateau time-signal intensity curve, while patients in the non-invasion group mainly showed rapid rising time-signal intensity curve (P<0.05). The serum levels of growth hormone and prolactin in the two groups at 1 week and 1 month after operation were both significantly lower than those before operation (P<0.05). There was no significant difference in the overall clinical efficacy between the invasive group and the non-invasive group (P>0.05). The tumor lesion of invasive pituitary adenoma was generally larger than that of non-invasive pituitary adenoma. The time-signal intensity curve of MRI was mainly of slow-rising type and plateau type, and endoscopic double-nostril approach for the treatment of invasive pituitary adenoma and non-invasive pituitary adenoma had a good effect.

Key words: invasive pituitary adenoma, magnetic resonance imaging, endoscopy, double nostril approach, growth hormone, prolactin

WANG Yanjun, ZHAO Decai, SUN Zheng, ZHANG Peng, LU Lei. Characteristics Analysis of MRI in the Diagnosis of Invasive Pituitary Adenomas and Effect Observation of the Surgical Effect of Endoscopic Double Nostril Approach[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 90-95.

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