18F-FDG PET/CT技术评价T2DM对晚期结直肠癌患者PD-L1治疗疗效的影响

doi:10.7517/issn.1674-0475.210831

影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (2): 237-242.DOI: 10.7517/issn.1674-0475.210831

¹⁸F-FDG PET/CT技术评价T2DM对晚期结直肠癌患者PD-L1治疗疗效的影响

张晓洁¹, 李娜², 杨芳², 侯倩倩², 李玲玲², 蔡红许²

1. 衡水市人民医院介入科, 河北衡水 053000;
2. 衡水市人民医院肿瘤内科, 河北衡水 053000

收稿日期:2021-08-25 出版日期:2022-03-15 发布日期:2022-03-08
通讯作者: 张晓洁
基金资助:
2019年衡水市科技计划自筹经费项目(2019014032Z)

The Value of ¹⁸F-FDG PET/CT Technology in Evaluating the Effect of T2DM on the Efficacy of PD-L1 Targeted Therapy in Patients with Advanced Colorectal Cancer

ZHANG Xiaojie¹, LI Na², YANG Fang², HOU Qianqian², LI Lingling², CAI Hongxu²

1. Interventional Department, Hengshui People's Hospital, Hengshui 053000, Hebei, P. R. China;
2. Oncology Department, Hengshui People's Hospital, Hengshui 053000, Hebei, P. R. China

Received:2021-08-25 Online:2022-03-15 Published:2022-03-08

摘要/Abstract

摘要： 本研究探讨氟代脱氧葡萄糖正电子发射计算机断层显像/计算机断层显像(¹⁸F-FDG PET/CT)技术评价2型糖尿病(T2DM)对晚期结直肠癌患者程序性死亡受体-1配体(PD-L1)治疗疗效的影响,选取104例晚期结直肠癌患者,根据是否伴有T2DM分为T2DM组(n=49)、无T2DM组(n=55)。比较两组疗效及¹⁸F-FDG PET/CT技术参数:平均标准摄取值(SUV_mean)、最大标准摄取值(SUV_max)、代谢体积(MTV)、病灶糖酵解总量(TLG),探讨¹⁸F-FDG PET/CT的应用价值。结果显示,T2DM组病理分期、疗效、SUV_mean、SUV_max、MTV、TLG与无T2DM组比较,差异有统计学意义(P<0.05);T2DM组、无T2DM组未缓解者SUV_mean、SUV_max、MTV、TLG均高于缓解者(P<0.05);T2DM组缓解者SUV_mean、SUV_max、MTV、TLG高于无T2DM组缓解者(P<0.05);SUV_mean、SUV_max、MTV、TLG与疗效呈负相关(P<0.05);SUV_mean、SUV_max、MTV联合TLG预测T2DM未缓解的价值最高。采用¹⁸F-FDG PET/CT技术联合检测SUV_mean、SUV_max、MTV、TLG能评价T2DM对晚期结直肠癌患者PD-L1靶向治疗疗效的影响,并能客观、量化预测患者的治疗反应性。

关键词: 氟代脱氧葡萄糖正电子发射计算机断层显像/计算机断层显像技术, 2型糖尿病, 晚期结直肠癌, 程序性死亡受体-1配体靶向治疗, 疗效

Abstract: This study explored the evaluation of ¹⁸F-fluorodeoxyglucose positron emission computed tomography/computed tomography (¹⁸F-FDG PET/CT) technology for the evaluation of type 2 diabetes (T2DM) on the programmed death receptor-1 ligand in patients with advanced colorectal cancer (PD-L1) The effect of treatment efficacy. A total of 104 patients with advanced colorectal cancer were selected, and they were divided into T2DM group (n=49) and no T2DM group (n=55) according to whether they were accompanied by T2DM. The efficacy and ¹⁸F-FDG PET/CT technical parameters:average standard uptake value (SUV_mean), maximum standard uptake value (SUV_max), metabolic volume (MTV), total glycolysis of lesions (TLG) were 237 compared between the two groups, and the application value of ¹⁸F-FDG PET/CT were explored. The results showed that the pathological staging, curative effect, SUV_mean, SUV_max, MTV, TLG of the T2DM group were compared with those without T2DM, and the difference was statistically significant (P<0.05); T2DM and T2DM without remission were SUV_mean, SUV_max, MTV, TLG SUVmean, SUV_max, MTV, and TLG in the T2DM group were higher than those in the non-T2DM group (P<0.05). SUV_mean, SUV_max, MTV, and TLG were negatively correlated with the efficacy (P<0.05). SUV_mean, SUV_max, MTV combined with TLG predict the highest value of T2DM unrelief. The combined detection of SUV_mean, SUV_max, MTV, and TLG with ¹⁸F-FDG PET/CT technology can evaluate the effect of T2DM on the efficacy of PD-L1 targeted therapy in patients with advanced colorectal cancer, and can objectively and quantitatively predict the patient’s response to treatment.

Key words: ¹⁸F-fluorodeoxyglucose positron emission computed tomography/computed tomography (¹⁸F-FDG PET/CT) technology, type 2 diabetes (T2DM), advanced colorectal cancer, programmed death-ligand 1 (PD-L1) targeted therapy, curative effect

张晓洁, 李娜, 杨芳, 侯倩倩, 李玲玲, 蔡红许. ¹⁸F-FDG PET/CT技术评价T2DM对晚期结直肠癌患者PD-L1治疗疗效的影响[J]. 影像科学与光化学, 2022, 40(2): 237-242.

ZHANG Xiaojie, LI Na, YANG Fang, HOU Qianqian, LI Lingling, CAI Hongxu. The Value of ¹⁸F-FDG PET/CT Technology in Evaluating the Effect of T2DM on the Efficacy of PD-L1 Targeted Therapy in Patients with Advanced Colorectal Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(2): 237-242.

参考文献

[1] 韩子翰, 陈佳佳, 冯楠, 等. 2型糖尿病合并结直肠癌的临床病理特征[J]. 中华胃肠外科杂志, 2019, 22(10):966-971.
[2] André T, Shiu K K, Kim T W, et al. Pembrolizumab in microsatellite-instability-high advanced colorectal cancer[J]. The New England Journal of Medicine, 2020, 383(23):2207-2218.
[3] Le D T, Kim T W, van Cutsem E, et al. Phase II open-label study of pembrolizumab in treatment-refractory, microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer:KEYNOTE-164[J]. Journal of Clinical Oncology, 2020, 38(1):11-19.
[4] Kleiner S, Weber W. Stellenwert der FDG-PET/computer tomographie beim kolorektalen karzinom[importance of FDG-PET/computed tomography in colorectal cancer[J]. Radiologe, 2019, 59(9):812-819.
[5] Rodríguez-Fraile M, Cózar-Santiago M P, Sabaté-Llobera A, et al. FDG PET/CT in colorectal cancer[J]. Revista Española De Medicina Nuclear e Imagen Molecular, 2020, 39(1):57-66.
[6] 国家卫生计生委医政医管局, 中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2017年版)[J]. 中华胃肠外科杂志, 2018, 21(1):92-106.
[7] 张萍, 艾斌. 实体瘤免疫治疗疗效评价标准[J]. 国际肿瘤学杂志, 2016, 43(11):848-851.
[8] Amin M N, Hussain M S, Sarwar M S, et al. How the association between obesity and inflammation may lead to insulin resistance and cancer[J]. Diabetology & Metabolic Syndrome, 2019, 13(2):1213-1224.
[9] Cheng H C, Chang T K, Su W C, et al. Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes[J]. Translational Oncology, 2021, 14(7):101089.
[10] Yoon J H, Lee J M, Chang W, et al. Initial M staging of rectal cancer:FDG PET/MRI with a hepatocyte-specific contrast agent versus contrast-enhanced CT[J]. Radiology, 2020, 294(2):310-319.
[11] Chulroek T, Kordbacheh H, Wangcharoenrung D, et al. Comparative accuracy of qualitative and quantitative ¹⁸F-FDG PET/CT analysis in detection of lymph node metastasis from anal cancer[J]. Abdominal Radiology, 2019, 44(3):828-835.
[12] Hasbek Z, Ozer H, Erturk S A, et al. Relationships between hypoxia induced factor-1α and ¹⁸F-FDG PET/CT parameters in colorectal cancer[J]. Revista Española De Medicina Nuclear E Imagen Molecular, 2019, 38(6):355-361.
[13] Yang Z G, Liu Z Y. The efficacy of ¹⁸F-FDG PET/CT-based diagnostic model in the diagnosis of colorectal cancer regional lymph node metastasis[J]. Saudi Journal of Biological Sciences, 2020, 27(3):805-811.
[14] Giannini V, Mazzetti S, Bertotto I, et al. Predicting locally advanced rectal cancer response to neoadjuvant therapy with ¹⁸F-FDG PET and MRI radiomics features[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2019, 46(4):878-888.
[15] Bashir U, Weeks A, Goda J S, et al. Measurement of ¹⁸F-FDG PET tumor heterogeneity improves early assessment of response to bevacizumab compared with the standard size and uptake metrics in a colorectal cancer model[J]. Nuclear Medicine Communications, 2019, 40(6):611-617.

¹⁸F-FDG PET/CT技术评价T2DM对晚期结直肠癌患者PD-L1治疗疗效的影响

The Value of ¹⁸F-FDG PET/CT Technology in Evaluating the Effect of T2DM on the Efficacy of PD-L1 Targeted Therapy in Patients with Advanced Colorectal Cancer

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