快速MRI联合母体血清标志物诊断孕中期胎儿CNS发育畸形

doi:10.7517/issn.1674-0475.211143

影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (3): 659-664.DOI: 10.7517/issn.1674-0475.211143

快速MRI联合母体血清标志物诊断孕中期胎儿CNS发育畸形

孙玲玲¹, 胡蓉², 胡晶晶³

1. 江苏医药职业学院护理学院, 江苏盐城 224005;
2. 江苏省人民医院老年科, 江苏南京 210000;
3. 江苏省人民医院妇产科, 江苏南京 210000

收稿日期:2021-11-19 出版日期:2022-05-15 发布日期:2022-05-27

Rapid MRI Combined with Maternal Serum Markers in the Diagnosis of Fetal CNS Developmental Malformations in the Second Trimester of Pregnancy

SUN Lingling¹, HU Rong², HU Jingjing³

1. Nursing School of Jiangsu Vocational College of Medicine, Yancheng 224005, Jiangsu, P. R. China;
2. The Department of Geriatrics, Jiangsu Province Hospital, Nanjing 210000, Jiangsu, P. R. China;
3. The Department of Obstetrics and Gynecology, Jiangsu Province Hospital, Nanjing 210000, Jiangsu, P. R. China

Received:2021-11-19 Online:2022-05-15 Published:2022-05-27

摘要/Abstract

摘要： 本文探讨快速磁共振成像(MRI)联合母体血清标志物检测诊断孕中期胎儿中枢神经系统(CNS)发育畸形的应用价值。选取112例孕中期疑似胎儿CNS发育畸形的孕妇作为研究对象,均进行MRI检查和母体血清标志物检测。结果显示,胎儿CNS发育畸形发生率为18.75%;快速MRI检出19例胎儿CNS畸形,其中真阳性18例;胎儿CNS畸形母体孕中期血清甲胎蛋白(AFP)、游离β-人绒毛膜促性腺激素(Free-β-hCG)水平高于未畸形母体,妊娠相关血浆蛋白A (PAPP-A)、游离雌三醇(uE3)水平低于未畸形母体(P＜0.05);母体血清AFP、Free-β-hCG、PAPP-A、uE3水平均为孕中期胎儿CNS畸形独立影响因素(P＜0.05);快速MRI联合母体血清AFP、Free-β-hCG、PAPP-A、uE3水平诊断孕中期胎儿CNS发育畸形的曲线下面积(AUC)为0.961。快速MRI联合母体血清标志物检测在孕中期胎儿CNS发育畸形诊断中具有较高的应用价值。

关键词: 胎儿中枢神经系统发育畸形, 快速MRI, 甲胎蛋白, 游离雌三醇, 妊娠相关血浆蛋白A, 游离β-人绒毛膜促性腺激素

Abstract: This paper explored the application value of rapid MRI combined with maternal serum marker detection in the diagnosis of fetal central nervous system (CNS) developmental malformations in the second trimester of pregnancy. Selected 112 pregnant women with suspected fetuses CNS developmental malformations in the second trimester of pregnancy as research objects, and all of them underwent MRI examination and maternal serum marker detection. The results showed that the incidence of fetal CNS malformation was 18.75%; 19 cases of fetal CNS malformation were detected by rapid MRI, of which 18 were true positive. The serum levels of alpha-fetoprotein (AFP) and free β-human chorionic gonadotropin (Free-β-hCG) in the second trimester of mothers with fetal CNS malformation were higher than those of non-malformed mothers, while the levels of pregnancy-associated plasma protein-A (PAPP-A) and free estriol (uE3) were lower than those of non-malformed mothers (P<0.05). The levels of maternal serum AFP, Free-β-hCG, PAPP-A and uE3 were all independent influencing factors of fetal CNS malformation in the second trimester of pregnancy (P＜0.05). The area under the curve (AUC) for fetal CNS developmental malformations through rapid MRI combined with maternal serum AFP, Free-β-hCG, PAPP-A and uE3 diagnosis was 0.961. Rapid MRI combined with maternal serum marker detection has a high application value in the diagnosis of fetal CNS developmental malformations in the second trimester pregnancy.

Key words: fetal central nervous system developmental malformations, rapid MRI, alpha-fetoprotein, free estriol, pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin

孙玲玲, 胡蓉, 胡晶晶. 快速MRI联合母体血清标志物诊断孕中期胎儿CNS发育畸形[J]. 影像科学与光化学, 2022, 40(3): 659-664.

SUN Lingling, HU Rong, HU Jingjing. Rapid MRI Combined with Maternal Serum Markers in the Diagnosis of Fetal CNS Developmental Malformations in the Second Trimester of Pregnancy[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(3): 659-664.

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快速MRI联合母体血清标志物诊断孕中期胎儿CNS发育畸形

Rapid MRI Combined with Maternal Serum Markers in the Diagnosis of Fetal CNS Developmental Malformations in the Second Trimester of Pregnancy

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