IVIM在移植肾排斥反应诊断中的应用

doi:10.7517/issn.1674-0475.211144

摘要/Abstract

摘要： 本研究探讨体素内不相干运动(IVIM)在移植肾排斥反应诊断中的应用价值。选取53例移植肾患者作为研究对象,根据病理结果分组,24例有急性排斥反应患者为排斥组,29例肾功能正常患者为非排斥组,分析排斥组和非排斥组IVIM参数差异。结果显示,排斥组肾皮质、肾髓质总体表观扩散系数(ADC_T)明显低于非排斥组(P＜0.05);排斥组和非排斥组肾皮质、肾髓质单纯表观扩散系数(ADC_D)、伪灌注表观扩散系数(ADC_P)和伪扩散所占的容积分数(F_P)比较差异无统计学意义(P＞0.05);细胞性排斥、体液性排斥、混合性排斥患者IVIM参数比较差异无统计学意义(P＞0.05);肾皮质、肾髓质ADCT诊断移植肾患者发生急性排斥反应的ROC曲线下面积分别为0.793和0.889,P＜0.05。IVIM扫描参数总体表观扩散系数在诊断移植肾排斥反应中有较好的应用价值。

关键词: 体素内不相干运动, 移植肾, 排斥反应, 诊断价值

Abstract: This study explored the application value of voxel incoherent motion (IVIM) in the diagnosis of renal transplantation rejection. 53 patients with renal transplantation were selected as the research object. According to the pathological results, there were 24 patients with acute rejection (rejection group) and 29 patients with normal renal function (non-rejection group), and analyzed the difference of IVIM parameters between rejection group and non-rejection group. The total apparent diffusion coefficients (ADC_T) of renal cortex and medulla in the rejection group were significantly lower than those in the non-rejection group (P<0.05). There were no significant differences in the pure diffusion apparent diffusion coefficient (ADC_D), pseudo perfusion apparent diffusion coefficient (ADC_P) and volume fraction of pseudo diffusion (F_P) in renal cortex and medulla between the rejection group and non-rejection group (P>0.05). There were no significant differences in IVIM parameters between patients with cellular rejection, humoral rejection and mixed rejection (P>0.05). The areas under the ROC curve of renal cortex and medulla ADC_T in the diagnosis of acute rejection of transplanted kidney patients were 0.793 and 0.889, respectively, P<0.05. The total apparent diffusion coefficient of IVIM scan parameter has a good application value in the diagnosis of renal transplantation rejection.

Key words: intravoxel incoherent motion, renal transplantation, rejection reaction, diagnostic value

范双莉, 王晓静, 范双园, 王玉强. IVIM在移植肾排斥反应诊断中的应用[J]. 影像科学与光化学, 2022, 40(3): 670-674.

FAN Shuangli, WANG Xiaojing, FAN Shuangyuan, WANG Yuqiang. Application of IVIM in the Diagnosis of Renal Transplantation Rejection[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(3): 670-674.

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