关键词: 简化关节超声评分, 类风湿关节炎, 关节炎症, 骨破坏, 病情转归

Abstract: This study investigate the relationship between the simplified joint ultrasound score and joint inflammation and bone destruction in patients with rheumatoid arthritis (RA), as well as the evaluation value of disease outcome. 112 patients with RA were selected as the research subjects, all of them received intensive treatment for 3 months. According to the disease outcome they were divided into an effective group (n=95) and an ineffective group (n=17). The scores of DAS28, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Wnt inhibitor Dickkopf-1, receptor activator of nuclear factor kappa B ligand (RANKL), and simplified ultrasound scores in the effective group were higher than those in the ineffective group, and all indexes were the influencing factors of RA disease outcome (P<0.05). The simplified joint ultrasound score of RA patients was positively correlated with DAS28 score, joint inflammation index ESR, CRP, bone destruction index Dickkopf-1, RANKL (P<0.05). The AUC of simplified joint ultrasound score and the final score which evaluated the prognosis of RA patients were higher than 0.7. Simplified joint ultrasound score is related to joint inflammation and bone destruction in RA patients, and could provide a strong reference for the evaluation of the disease outcome of RA up-to-standard treatment, and provide a basis for timely effective and individualized treatment.

Key words: simplified joint ultrasound score, rheumatoid arthritis, joint inflammation, bone destruction, disease outcome