DCE-MRI对上皮性卵巢癌的诊断价值及与微血管密度的关系

doi:10.7517/issn.1674-0475.220114

摘要/Abstract

摘要： 本文探讨动态对比增强磁共振成像（DCE-MRI）对上皮性卵巢癌的诊断价值及与患者微血管密度的关系。选取60例上皮性卵巢癌患者作为观察组，另选取同期收治的60例良性卵巢肿瘤患者作为对照组，均进行DCE-MRI检查，获取最大浓度（Cmax）、浓度-时间曲线下面积（AUC）、最大斜率（MS）、速率常数（Kep）、转运常数（Ktrans）、血管外细胞间隙体积分数（Ve），并采用免疫组化SABC法检测微血管密度。结果显示，观察组Cmax、AUC、MS、Kep、Ktrans、Ve高于对照组，TTP低于对照组（P<0.05）；Ktrans、Kep、Ve、TTP、Cmax、AUC、MS均与上皮性卵巢癌发病独立相关（P<0.05）；DCE-MRI各参数联合微血管密度诊断的ROC曲线下面积为0.915，较上述单一诊断价值更高；观察组微血管密度高于对照组（P<0.05），上皮性卵巢癌患者Ktrans、Kep、Ve、Cmax、AUC、MS与微血管密度呈正相关关系，TTP与微血管密度呈负相关关系（P<0.05）。DCE-MRI通过定量分析诊断上皮性卵巢癌，具有良好诊断效能，且其定量及半定量参数均与微血管密度有关。

关键词: 动态对比增强磁共振成像, 上皮性卵巢癌, 微血管密度, 定量参数, 半定量参数

Abstract: This paper explored the diagnostic value of dynamic enhanced magnetic resonance imaging (DCE-MRI) on epithelial ovarian cancer and its relationship with the microvessel density. 60 patients with epithelial ovarian cancer were selected as the observation group, and 60 patients with benign ovarian tumors admitted during the same period were selected as the control group. All patients underwent DCE-MRI examination, then got the date of maximum concentration (Cmax), area under the concentration-time curve (AUC), maximum slope (MS), rate constant (Kep), transport constant (Ktrans), extravascular cell space volume fraction (Ve), and detected the microvessel density by immunohistochemical SABC method. The results showed that the Cmax, AUC, MS, Kep, Ktrans, Ve of observation group were higher than those of control group, except TTP (P<0.05). The Ktrans, Kep, Ve, TTP, Cmax, AUC, MS were all independently related to the onset of epithelial ovarian cancer (P<0.05). The area under curve of ROC in DCE-MRI combined with microvessel density diagnosis was 0.915, which was more valuable than the single diagnosis above. The microvessel density of patients in the observation group was higher than that in the control group (P<0.05).The Ktrans, Kep, Ve, Cmax, AUC, MS were positively correlated with microvessel density in patients with epithelial ovarian Abstract:cancer, and TTP was negatively correlated with microvessel density (P<0.05). Therefore, DCE-MRI has good diagnostic performance in the diagnosis of epithelial ovarian cancer through quantitative analysis, and its quantitative and semi-quantitative parameters are both related to microvessel density.

Key words: dynamic enhanced magnetic resonance imaging, epithelial ovarian cancer, microvessel density, quantitative parameters, semi-quantitative parameters

封捷, 李梦双, 段新秀. DCE-MRI对上皮性卵巢癌的诊断价值及与微血管密度的关系[J]. 影像科学与光化学, 2022, 40(4): 832-836.

FENG Jie, LI Mengshuang, DUAN Xinxiu. The Diagnostic Value of DCE-MRI on Epithelial Ovarian Cancer and Its Relationship with Microvessel Density[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 832-836.

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