CDFI鉴别男性乳腺良恶性肿瘤价值及与CXCL1、Gab2、MVD的相关性探究

doi:10.7517/issn.1674-0475.200601

摘要/Abstract

摘要： 本研究选取18例男性乳腺恶性肿瘤患者作为研究组，纳入同期41例男性良性乳腺肿瘤及50例健康体检男性分别作为良性对照组和健康对照组，通过对比分析发现，研究组CDFI参数[搏动指数（PI）、阻力指数（RI）、血流速度（PSV）]高于良性对照组和健康对照组（P<0.05）；PI、RI、PSV联合诊断男性乳腺恶性肿瘤的AUC高达0.854，具有较高应用价值；研究组患者PI、RI、PSV与CXC型趋化因子配体1（CXCL1）、GRB相关蛋白2（Gab2）、微血管密度（MVD）水平间存在正相关关系（P<0.05）。由此可见，CDFI在鉴别男性乳腺良恶性肿瘤方面具有较高应用价值，且与患者CXCL1、Gab2、MVD表达呈正相关。

关键词: 乳腺癌, 男性, 彩色多普勒超声, CXC型趋化因子配体1, GRB相关蛋白2, 微血管密度

Abstract: In this article, 18 male patients with malignant breast tumors were selected as the research group, while 41 male with benign breast tumors and 50 healthy males in the same period were included as benign control group and healthy control group. Through comparative analysis, it was found that the CDFI parameters[pulse index (PI), resistance index (RI), blood flow velocity (PSV)] of the research group were higher than those of the benign control group and the healthy control group (P<0.05). The combined AUC value of PI, RI and PSV in the diagnosis of male breast malignant tumors was as high as 0.854, which was of a high application value. In the research group, there was a positive correlation between PI, RI, PSV and the level of CXC type chemokine ligand 1 (CXCL1), as well as the level of GRB related protein 2 (Gab2) and microvessel density (MVD) (P<0.05). Our research showed that CDFI had a high application value in identifying benign and malignant breast tumors in men, and it is positively correlated with the expression of CXCL1, Gab2 and MVD in patients.

Key words: breast cancer, male, color doppler flow imaging, CXC-type chemokine ligand 1, GRB-related protein 2, microvessel density

吴肖升, 刘洋, 吴葆辉. CDFI鉴别男性乳腺良恶性肿瘤价值及与CXCL1、Gab2、MVD的相关性探究[J]. 影像科学与光化学, 2021, 39(1): 139-144.

WU Xiaosheng, LIU Yang, WU Baohui. The Value of CDFI in Identifying Benign and Malignant Tumors of Male Breast and Its Correlation with CXCL1, Gab2 and MVD[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(1): 139-144.

参考文献

[1] 刘畅. 老年男性乳腺癌27例超声诊断分析[J]. 肿瘤学杂志, 2018, 24(9):934-935.
[2] Silvestri V, Rizzolo P, Zelli V, et al. A possible role of FANCM mutations in male breast cancer susceptibility:results from a multicenter study in Italy[J]. Breast, 2018, 38(1):92-97.
[3] Yang G C H, Fried K O. Most thyroid cancers detected by sonography lack intranodular vascularity on color Doppler imaging:review of the literature and sonographic-pathologic correlations for 698 thyroid neoplasms[J]. Journal of Ultrasound in Medicine, 2017, 36(1):89-94.
[4] 付贝, 沈夏平, 马超, 等. 乳腺癌患者DCE-MRI各参数与MVD、VEGF的关系及其临床诊断价值[J]. 中国医学计算机成像杂志, 2019, 25(2):197-202.
[5] Duckworth C, Zhang L, Carroll S L, et al. Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression[J]. Oncogene, 2016, 35(31):4036-4047.
[6] 《肿瘤病理诊断规范》项目组. 肿瘤病理诊断规范(乳腺癌)[J]. 中华病理学杂志, 2016, 45(8):525-528.
[7] 邱凯涛, 姚海东, 刘娜. 超声与数字钼靶X线摄影及两者联合对不同级别乳腺导管原位癌的诊断价值[J]. 中国医学创新, 2017, 14(6):13-16.
[8] 张慧, 陈思佳, 张鸿, 等. 乳腺癌超声弹性成像定量参数与病灶内癌细胞凋亡、侵袭异常的相关性分析[J]. 海南医学院学报, 2018, 24(3):398-401.
[9] 周娜, 丁洁, 杨汇娟. 彩色多普勒血流成像联合血清CA125、CA724检测对卵巢良恶性肿瘤的鉴别诊断效能[J]. 中国临床研究, 2019, 32(6):779-783.
[10] 陈海涛, 杨丽春, 罗晓茂, 等. 超声造影参数对乳腺肿瘤性质的评估价值及其与肿瘤恶性生物学行为的相关关系[J]. 海南医学院学报, 2017, 23(24):3463-3466.
[11] Rong X, Zhu Q, Jia W, et al. Ultrasonographic assessment of male breast diseases[J]. Breast Journal, 2018, 24(4):599-605.
[12] 苏彤, 赵燕妹, 张玲, 等. 多模态超声评估乳腺癌新辅助化疗的价值[J]. 南京医科大学学报(自然科学版), 2019, 39(3):107-110.
[13] 牛秋云. 彩色多普勒超声在乳腺良恶性肿瘤临床诊断鉴别中的应用[J]. 影像研究与医学应用, 2020, 4(2):127-128.
[14] 侯丽红. 彩色多普勒超声在乳腺实性结节性质诊断及鉴别诊断中的应用价值[J]. 医疗装备, 2019, 32(4):33-34.
[15] 杨诚诚, 陶凯, 喻浩宸, 等. 沉默CXCL1基因抑制三阴性乳腺癌细胞MDA-MB-231的迁移、侵袭的研究[J]. 基因组学与应用生物学, 2019, 38(1):455-460.
[16] Kim E K, Moon S, Kim D K, et al. CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma[J]. PLoS One, 2018, 13(1):e0188847.
[17] 杨庭松, 孙营营, 张小兵, 等. CXCL-1促进胃癌细胞迁移和侵袭机制探讨[J]. 中华肿瘤防治杂志, 2017, 24(13):881-887.
[18] 冯敏, 邢人鑫, 邢薇, 等. Gab2在卵巢癌中的表达及其与铂类药物化疗耐药的相关性研究[J]. 重庆医学, 2017, 46(21):2931-2933.
[19] 张绪美, 张燕, 陈敏. IgG、Gab2、PTEN在人脑胶质瘤中的表达及其临床意义[J]. 实用医学杂志, 2018, 34(9):65-67, 72.
[20] 徐新伟, 李佩瑞, 张增山, 等. miR-125a-5p通过靶向调控GAB2抑制乳腺癌细胞的迁移能力[J]. 中国生物化学与分子生物学报, 2017, 33(9):925-930.
[21] 彭大颖, 姜丽红, 吴迪. 乙酰肝素酶mRNA及CD34在乳腺癌组织中的表达与病理特征及MVD的关系研究[J]. 癌症进展, 2017, 15(11):1305-1307.
[22] 崔艳婷, 谢小红, 顾锡冬, 等. 乳腺癌患者MVD VEGF与Ki-67淋巴结转移的相关性分析[J]. 浙江临床医学, 2018, 20(1):12-14.
[23] 喻宏, 李晓星, 贾晓敏. CD133、MVD在三阴乳腺癌组织中的表达及其意义[J]. 医学临床研究, 2017, 34(10):1938-1940.