SWE联合尿脱落细胞学检测对膀胱尿路上皮癌级别鉴定的价值

doi:10.7517/issn.1674-0475.221022

影像科学与光化学 ›› 2023, Vol. 41 ›› Issue (1): 53-58.DOI: 10.7517/issn.1674-0475.221022

SWE联合尿脱落细胞学检测对膀胱尿路上皮癌级别鉴定的价值

杨贝贝¹, 徐金芝², 郑小菊¹

1. 信阳职业技术学院医学院, 河南信阳 464000;
2. 信阳职业技术学院附属医院, 河南信阳 464099

收稿日期:2022-10-18 出版日期:2023-01-23 发布日期:2023-01-31
通讯作者: 郑小菊
基金资助:
河南卫生健康委员会基金项目（WJLX2021210）

The Value of SWE Combined with Urinary Exfoliative Cytology Detection in the Identification of Bladder Urothelial Carcinoma Grades

YANG Beibei¹, XU Jinzhi², ZHENG Xiaoju¹

1. Medical College of Xinyang Vocational and Technical College, Xinyang 464000, Henan, P. R. China;
2. The Affiliated Hospital of Xinyang Vocational and Technical College, Xinyang 464099, Henan, P. R. China

Received:2022-10-18 Online:2023-01-23 Published:2023-01-31

摘要/Abstract

摘要： 本研究探讨剪切波弹性成像技术（SWE）联合尿脱落细胞检测在诊断膀胱尿路上皮癌及级别判断中的应用。选取经病理学检查证实为膀胱尿路上皮癌的87例患者为病例组、85例单纯尿路上皮增生患者作为对照组，对比两组患者的常规超声特征参数、SWE参数、尿脱落细胞的荧光原位杂交技术（FISH）检测结果，并按照病理学分级结果将病例组进行分层分析。对比病例组和对照组的超声参数，病例组的病灶血流丰富率、内部回声不均匀率、肿瘤病灶多发率、表面特征不光滑率均显著高于对照组（P<0.05）；病例组的病灶SWE参数Emax、Emean、Emin均显著高于对照组（P<0.05）；病例组的FISH检测结果阳性率高于对照组（P<0.05）；高级别的膀胱尿路上皮癌患者病灶血流丰富率、表面特征不光滑率显著高于低级别病变患者（P<0.05）；高级别的膀胱尿路上皮癌患者SWE参数Emax、Emean、Emin均显著高于低级别病变患者（P<0.05）；高级别的膀胱尿路上皮癌患者的FISH检测结果阳性率高于低级别患者（P<0.05）。SWE和尿脱落细胞检测对膀胱尿路上皮癌诊断及病变级别评估具有较高的临床实用价值。

关键词: 剪切波弹性成像技术, 尿脱落细胞, 膀胱尿路上皮癌, 超声, 荧光原位杂交技术

Abstract: This study investigated the application of shear wave elastography (SWE) combined with the urinary exfoliated cells detection in the diagnosis and grade judgment of bladder urothelial carcinoma. 87 patients with bladder urothelial carcinoma confirmed by pathological examination were selected as the case group, and 85 patients with simple urothelial hyperplasia were selected as the control group. The routine ultrasound characteristic parameters, SWE parameters, and fluorescence in situ hybridization (FISH) detection results of urinary exfoliated cells were compared between the two groups of patients, and the case groups were stratified according to the pathological grading results. Compared the ultrasound parameters of the case group and the control group, the rich lesion blood flow characteristics, the internal echo inhomogeneous rate, the multiple tumor lesion rate, and the surface roughness rate in the case group were significantly higher than those in the control group (P<0.05). The lesion SWE parameters Emax, Emean and Emin of the case group were significantly higher than those of the control group (P<0.05), the positive rate of FISH in the case group was higher than that in the control group (P<0.05). In patients with high-grade bladder urothelial carcinoma, the blood flow enrichment rate and the surface feature roughness rate of lesions were significantly higher than those in patients with low-grade lesions (P<0.05). The SWE parameters Emax, Emean and Emin of patients with high-grade bladder urothelial carcinoma were significantly higher than those of patients with low-grade lesions (P<0.05). The positive rate of FISH in patients with high-grade bladder urothelial carcinoma was higher than that in low-grade patients (P<0.05). The detection of SWE and urinary exfoliated cells has high clinical value in the diagnosis of bladder urothelial carcinoma and the assessment of lesion grade.

Key words: shear wave elastography, urine exfoliated cells, bladder urothelial carcinoma, ultrasound, fluorescence in situ hybridization

杨贝贝, 徐金芝, 郑小菊. SWE联合尿脱落细胞学检测对膀胱尿路上皮癌级别鉴定的价值[J]. 影像科学与光化学, 2023, 41(1): 53-58.

YANG Beibei, XU Jinzhi, ZHENG Xiaoju. The Value of SWE Combined with Urinary Exfoliative Cytology Detection in the Identification of Bladder Urothelial Carcinoma Grades[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 53-58.

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SWE联合尿脱落细胞学检测对膀胱尿路上皮癌级别鉴定的价值

The Value of SWE Combined with Urinary Exfoliative Cytology Detection in the Identification of Bladder Urothelial Carcinoma Grades

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