磁共振弥散加权成像联合配对盒基因5诊断乳腺病变的研究

doi:10.7517/issn.1674-0475.221027

摘要/Abstract

摘要： 本文考察了磁共振弥散加权成像（DWI）联合配对盒基因5（PAX5）对乳腺病变的诊断价值。共纳入行DWI检查的107例乳腺病变患者（126个病灶），包括良性病变患者（54例，69个病灶）和恶性病变患者（53例，57个病灶），获得患者的表观扩散系数（ADC）、慢速表观扩散系数（ADC-slow）、扩散异质性指数（α）和扩散分布指数（DDC）。通过ELISA法检测良性病变患者和恶性病变患者血清PAX5水平。结果显示，恶性组的ADC、ADC-slow、α和DDC均显著低于良性组（P<0.001）。恶性组的血清PAX5水平显著低于良性组。血清PAX5与ADC、ADC-slow和DDC显著正相关（P<0.05）。ADC、ADC-slow、α和DDC诊断恶性病变的AUC依次为0.737、0.757、0.689和0.837，血清PAX5诊断恶性病变的AUC为0.853。DWI参数联合血清PAX5诊断恶性病变的AUC （0.973）、敏感性（100.00%）和特异性（88.41%）均高于单独诊断。DWI参数（ADC、ADC-slow、α和DDC）联合血清PAX5诊断恶性病变的价值均高于单独诊断，具有较高的临床推广价值。

关键词: 3.0T磁共振弥散加权成像, 配对盒基因5, 乳腺病变, 联合诊断, 表观扩散系数

Abstract: This study explored the diagnostic value of magnetic resonance diffusion-weighted imaging (DWI) combined with paired box gene 5 (PAX5) in breast lesions. 107 patients with breast lesions (126 lesions) underwent DWI examination in our hospital were selected, which including benign lesions (54 cases, 69 lesions) and malignant lesions (53 cases, 57 lesions). The apparent diffusion coefficient (ADC), slow apparent diffusion coefficient (ADC-slow), diffusion heterogeneity index (α), and diffusion distribution index (DDC) were obtained through DWI examination. Serum PAX5 levels in patients with benign and malignant lesions were detected by ELISA. The results showed that ADC, ADC-SLOW, α and DDC in the malignant group were significantly lower than those in the benign group (P<0.001). The serum PAX5 level in the malignant group was significantly lower than that in the benign group. Serum PAX5 was significantly positively correlated with ADC, ADC-slow and DDC (P<0.05). The AUC of ADC, ADC-slow, α and DDC in the diagnosis of malignant lesions were 0.737, 0.757, 0.689 and 0.837 respectively. The AUC of serum PAX5 for the diagnosis of malignant lesions was 0.853. The AUC (0.973), sensitivity (100.00%) and specificity (88.41%) of DWI parameters combined with serum PAX5 in the diagnosis of malignant lesions were higher than those of single diagnosis. This study shows that the value of DWI parameters (ADC, ADC-slow, α and DDC) combined with serum PAX5 in the diagnosis of malignant lesions is higher than that of single diagnosis, and has a high clinical value.

Key words: 3.0T magnetic resonance diffusion-weighted imaging, paired box gene 5, breast lesions, combined diagnosis, apparent diffusion coefficient

何炯明, 魏澄. 磁共振弥散加权成像联合配对盒基因5诊断乳腺病变的研究[J]. 影像科学与光化学, 2023, 41(1): 124-129.

HE Jiongming, WEI Cheng. Study of Magnetic Resonance Diffusion-weighted Imaging Combined with Paired Box Gene 5 in the Diagnosis of Breast Lesion[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 124-129.

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