联合低频振幅和度中心性的高度近视患者脑功能研究

doi:10.7517/issn.1674-0475.230601

影像科学与光化学 ›› 2023, Vol. 41 ›› Issue (5): 230-237.DOI: 10.7517/issn.1674-0475.230601

联合低频振幅和度中心性的高度近视患者脑功能研究

张晓盼¹, 杨帆², 金学民², 程敬亮¹, 文宝红¹

1. 郑州大学第一附属医院磁共振科, 河南郑州 450052;
2. 郑州大学第一附属医院眼科, 河南郑州 450052

收稿日期:2023-06-20 出版日期:2023-09-23 发布日期:2023-10-28
通讯作者: 文宝红
基金资助:
河南省重点研发与推广专项(科技攻关)(222102310317, 232102310094)、郑州大学第一附属医院院内青年创新基金项目(YNQN2017160)资助

A Brain Function Study of Combining Amplitude of Low Frequency Fluctuations and Degree Centrality in Patients with High Myopia

ZHANG Xiaopan¹, YANG Fan², JIN Xuemin², CHENG Jingliang¹, WEN Baohong¹

1. Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, P.R. China;
2. Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, P.R. China

Received:2023-06-20 Online:2023-09-23 Published:2023-10-28

摘要/Abstract

摘要： 探讨联合低频振幅(ALFF)和度中心性(DC)方法在高度近视(HM)患者静息状态下局部大脑的功能变化。选取45例患者作为HM组,选择与之匹配的46例双眼正常视力参与者作为对照组。所有被试进行静息态功能磁共振成像扫描。ALFF和DC的方法进行局部脑功能差异的分析。组间比较采用基于体素层面的独立样本t检验。结果显示与对照组相比,HM组在左眶部额下回、右距状裂周围皮层、右前扣带与旁扣带脑回、左丘脑、左顶下缘角回、右顶下缘角回和左中央旁小叶的ALFF值存在统计学差异(P＜0.05);HM组在右颞下回、左颞下回、右前扣带与旁扣带脑回、左眶内额上回、左距状裂周围皮层、右梭状回、左顶下缘角回和左中央旁小叶的DC值存在统计学差异(P＜0.05)。联合低频振幅和度中心性在HM患者大脑神经元活动及脑功能网络改变判断中具有较高的应用价值。

关键词: 高度近视, 静息态功能磁共振成像, 低频振幅, 度中心性

Abstract: To explore the abnormal changes of local brain function in patients with high myopia (HM) during the resting state by a combining amplitude of low frequency fluctuations (ALFF) and degree centrality (DC) method. A total of 45 HM patients were selected as the HM group, and 46 subjects with normal binocular vision were selected as the control group. All subjects underwent a resting-state functional magnetic resonance imaging scan. Altered local brain function was analyzed by using combined ALFF and DC. Comparison between groups was performed by two-sample t test based on voxel level. The results showed that compared with the control group, (1) there were widespread ALFF differences between groups throughout the left Inferior frontal gyrus, orbital part; right calcarine fissure and surrounding cortex; right anterior cingulate and paracingulate gyri; left thalamus; left inferior parietal, but supramarginal and angular gyri; right inferior parietal, but supramarginal and angular gyri and left paracentral lobule (P＜0.05); (2) there were widespread DC differences between groups throughout the right inferior temporal gyrus; left inferior 230 temporal gyrus; right anterior cingulate and paracingulate gyri; left superior frontal gyrus, medial orbital; left calcarine fissure and surrounding cortex; right fusiform gyrus; left inferior parietal, but supramarginal and angular gyri and left paracentral lobule (P＜0.05). The combination of low-frequency amplitude and degree centrality has high application value in the judgment of brain neuronal activity and brain functional network changes in HM patients.

Key words: high myopia, resting-state functional magnetic resonance imaging, amplitude of low frequency fluctuations, degree centrality

张晓盼, 杨帆, 金学民, 程敬亮, 文宝红. 联合低频振幅和度中心性的高度近视患者脑功能研究[J]. 影像科学与光化学, 2023, 41(5): 230-237.

ZHANG Xiaopan, YANG Fan, JIN Xuemin, CHENG Jingliang, WEN Baohong. A Brain Function Study of Combining Amplitude of Low Frequency Fluctuations and Degree Centrality in Patients with High Myopia[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(5): 230-237.

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联合低频振幅和度中心性的高度近视患者脑功能研究

A Brain Function Study of Combining Amplitude of Low Frequency Fluctuations and Degree Centrality in Patients with High Myopia

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