可注射性骨修复材料不饱和聚磷酸酯的光引发交联聚合

doi:10.7517/j.issn.1674-0475.2006.01.28

影像科学与光化学 ›› 2006, Vol. 24 ›› Issue (1): 28-35.DOI: 10.7517/j.issn.1674-0475.2006.01.28

可注射性骨修复材料不饱和聚磷酸酯的光引发交联聚合

邱进俊^1,2, 刘承美^1,3, 包瑞¹, 郑启新², 郭小东²

1. 华中科技大学, 化学系, 湖北, 武汉, 430074;
2. 华中科技大学, 生命科学与技术学院, 湖北, 武汉, 430074;
3. 华中科技大学, 塑性成形模拟及模具技术国家重点实验室, 湖北, 武汉, 430074

收稿日期:2005-08-30 修回日期:2005-10-21 出版日期:2006-01-23 发布日期:2006-01-23
通讯作者: 刘承美(1965-), 男, 副教授, 研究方向:光电功能高分子及生物医用高分子材料.
基金资助:
湖北省自然科学基金创新群体研究项目(2004ABC001).

Photocrosslinking Behavior of Unsaturated Polyphosphoester Used as An Injectable Bone Repair Material

QIU Jin-jun^1,2, LIU Cheng-mei^1,3, BAO Rui¹, ZHENG Qi-xin², GUO Xiao-dong²

1. Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P.R. China;
2. College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P.R. China;
3. State Key Laboratory of Plastic Forming Simulating and Die&Mould Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P.R. China

Received:2005-08-30 Revised:2005-10-21 Online:2006-01-23 Published:2006-01-23

摘要/Abstract

摘要： 通过凝胶含量的测定,研究了紫外光引发不饱和聚磷酸酯(UPPE)与 N-乙烯基吡咯烷酮的共聚交联反应.结果表明:加入光引发剂能够显著增加凝胶含量,安息香乙醚(BE),安息香(BN),2,2-二乙氧基苯乙酮的引发活性较高.光引发剂浓度较低时,增加光引发剂的含量能够显著提高单位时间内的凝胶生成率,但含量过大反而降低凝胶生成率.BN、BE的适宜浓度分别为2.4E^-5(mol/g UPPE)及0.6E^-5(mol/g UPPE).光照较短时间内,UPPE分子量为5960 g/mol的体系具有最高的凝胶生成率,但由于粘度的影响,光照2 min后其凝胶生成率低于UPPE分子量为4040 g/mol的体系.表层对紫外光的吸收降低了光能量,导致深层交联聚合反应速度降低,1.5 mm厚试样通过延长曝光时间,凝胶含量可与1.0 mm厚试样接近,6.0 mm试样曝光24 min后底层仍不能固化.

关键词: 不饱和聚磷酸酯, 可注射性骨修复材料, 光交联, 凝胶含量

Abstract: The UV crosslinking reaction of unsaturated polyphosphoester with N-vinyl pyrrolidone was investigated by gel content measurement. The experiment results show that photoinitiators can remarkably improve the gel content of curing product. Among all initiators used in this study, BE, BN and DEAP show high initiating activities. The gel content of curing product increased with the increasing of initiator amount within low concentration, but higher concentration of photoinitiator would reduce the gel content. The optimum amount of BN and BE was 2.4E^-5(mol/g UPPE)and 0.6E^-5(mol/g UPPE), respectively. The gel content of crosslinked network obtained from unsaturated polyphosphoester with M_w = 4040 g·mol^-1 is lower than that of with higher molecular weight when the irradiation time was less than 2 minutes, but an opposite results would obtained by extending irradiation time. The surface layer of sample absorbed the UV light and decreased the pho-tocrosslinking reaction rate of the deep layer. Gel content of the sample with 1.5 mm in thickness would approach to that of sample with 1.0 mm in thickness by extending irradiation time. The crosslinking reaction was uncompleted for the sample with 6.0 mm in thickness after 24 min irradiation.

Key words: unsaturated polyphosphoester, injectable bone repair materials, photocrosslinking, Gel content

中图分类号:

邱进俊, 刘承美, 包瑞, 郑启新, 郭小东. 可注射性骨修复材料不饱和聚磷酸酯的光引发交联聚合[J]. 影像科学与光化学, 2006, 24(1): 28-35.

QIU Jin-jun, LIU Cheng-mei, BAO Rui, ZHENG Qi-xin, GUO Xiao-dong. Photocrosslinking Behavior of Unsaturated Polyphosphoester Used as An Injectable Bone Repair Material[J]. Imaging Science and Photochemistry, 2006, 24(1): 28-35.

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可注射性骨修复材料不饱和聚磷酸酯的光引发交联聚合

Photocrosslinking Behavior of Unsaturated Polyphosphoester Used as An Injectable Bone Repair Material

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