IVUS对冠脉粥样硬化斑块及滋养血管的判断

doi:10.7517/issn.1674-0475.210518

摘要/Abstract

摘要： 本研究探讨血管内超声（IVUS）对冠状动脉粥样硬化性斑块及滋养血管的判断。选取急性冠脉综合征（ACS）患者38例，稳定型心绞痛（SAP）患者52例，所有患者给予IVUS检查，同时采用ELISA法检测冠心病患者血清脂蛋白相关的磷脂酶A2（Lp-PLA2）。ACS组血管重塑指数、斑块偏心指数、坏死组织面积、易损斑块总发生率、血清Lp-PLA2明显高于SAP组（P<0.05）；ACS组钙化组织面积、纤维组织面积和脂质/坏死组织面积明显低于SAP组（P<0.05）；冠心病患者血清Lp-PLA2与IVUS参数血管重塑指数、脂质/坏死组织面积呈正相关；ACS组最小管腔截面处、近端截面处和远端截面处滋养血管数明显多于SAP组（P<0.05）。IVUS显示ACS患者易损斑块以及滋养血管数明显高于SAP患者，IVUS部分参数与患者血清Lp-PLA2有相关性。

关键词: 血管内超声, 斑块, 滋养血管, 急性冠脉综合征, 稳定型心绞痛

Abstract: This study was to investigate the value of intravascular ultrasound (IVUS) in the diagnosis of coronary atherosclerotic plaque and nourishing blood vessels. A total of 38 patients with acute coronary syndrome (ACS) and 52 patients with stable angina pectris (SAP) were selected. All patients were given IVUS examination. Meanwhile, serum lipoprotein associated phospholipase A2 (LP-PLA2) was detected by ELISA in patients with coronary heart disease. The vascular remodeling index, plaque eccentricity index, necrotic tissue area, the total incidence of vulnerable plaque and serum Lp-PLA2 in ACS group were significantly higher than those in SAP group (P<0.05), the calcified tissue area, fibrous tissue area and lipid/necrotic tissue area were significantly lower than SAP group (P<0.05). Serum Lp-PLA2 was positively correlated with IVUS parameters vascular remodeling index and lipid/necrotic tissue area. The number of nutrient vessels at the minimal lumen section, proximal section and distal section in ACS group were significantly more than those in SAP group (P<0.05). IVUS showed that the incidence of vulnerable plaque and the number of plaque nourishing vessels in ACS patients are significantly higher than those in SAP patients, some parameters of IVUS are correlated with serum Lp-PLA2.

Key words: intravascular ultrasound, plaque, nutrient vessels, acute coronary syndrome, stable angina pectoris

席建芬, 郭莉, 贾晓静. IVUS对冠脉粥样硬化斑块及滋养血管的判断[J]. 影像科学与光化学, 2021, 39(6): 883-887.

XI Jianfen, GUO Li, JIA Xiaojing. IVUS in the Diagnosis of Coronary Atherosclerotic Plaque and Nutrient Vessels[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(6): 883-887.

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