CTA评估缺血性脑卒中合并T2DM患者颈动脉斑块特征与血Hcy、Cys-C、ApoA1及UA的相关性

doi:10.7517/issn.1674-0475.220623

摘要/Abstract

摘要： 本研究探讨缺血性脑卒中合并2型糖尿病（T2DM）患者颈动脉CT血管造影（CTA）评估颈动脉斑块特征与患者血清同型半胱氨酸（Hcy）、胱抑素C （Cys-C）、载脂蛋白A1（ApoA1）及尿酸（UA）水平的相关性。选取130例缺血性脑卒中伴T2DM患者作为病例组、65例单纯T2DM患者作为对照组，检测两组患者的血清Hcy、Cys-C、ApoA1及UA水平并进行对比；病例组接受CTA检查，分析不同颈动脉狭窄程度、斑块特征患者上述指标的差异情况。病例组患者的血清Hcy、Cys-C及UA水平均显著高于对照组，病例组患者的ApoA1水平低于对照组（P<0.05）；不稳定型斑块组患者的血清Hcy、Cys-C及UA水平均显著高于稳定型斑块组，不稳定型斑块组患者的ApoA1水平低于稳定型斑块组（P<0.05）；重度狭窄患者的血清UA水平均显著高于轻中度狭窄患者，重度狭窄患者的ApoA1水平低于轻中度狭窄患者（P<0.05）。CTA评估能较为准确地评估缺血性脑卒中合并T2DM患者颈动脉狭窄及斑块特征，同时Hcy、Cys-C、ApoA1及UA水平变化与斑块特征及颈动脉狭窄程度有一定关联性。

关键词: 缺血性脑卒中, 2型糖尿病, 颈动脉斑块, CT血管造影, 同型半胱氨酸, 胱抑素C, 载脂蛋白A1, 尿酸

Abstract: This study investigated the relationship between carotid artery plaque characteristics and serum homocysteine (Hcy), cystatin C (Cys-C), apolipoprotein A1 (ApoA1) and uric acid (UA) levels in patients with ischemic stroke complicated with type 2 diabetes mellitus (T2DM) assessed by carotid CT angiography (CTA). 130 ischemic stroke patients with T2DM were selected as the case group, and 65 patients with pure T2DM were selected as the control group. The serum Hcy, Cys-C, ApoA1 and UA levels of the two groups were detected and compared. The case group underwent CTA examination, and the differences of the above indicators in patients with different carotid artery stenosis degrees and plaque characteristics were analyzed. The serum Hcy, Cys-C and UA levels in the case group were significantly higher than those in the control group, and the ApoA1 level in the case group was lower than that in the control group (P<0.05). The serum levels of Hcy, Cys-C and UA in the unstable plaque group were significantly higher than those in the stable plaque group, and the ApoA1 level in the unstable plaque group was lower than that in the stable plaque group (P<0.05). Serum UA levels in patients with severe stenosis were significantly higher than those in patients with mild-to-moderate stenosis, and ApoA1 levels in patients with severe stenosis were lower than those in patients with mild-to-moderate stenosis (P<0.05). CTA assessment can accurately assess the characteristics of carotid artery stenosis and plaque in patients with ischemic stroke complicated with T2DM, at the same time, the changes of Hcy, Cys-C, ApoA1 and UA levels are correlated with plaque characteristics and the degree of carotid artery stenosis.

Key words: ischemic stroke, type 2 diabetes, carotid plaque, CT angiography, homocysteine, cystatin C, apolipoprotein A1, uric acid

金兆维, 马飞龙, 张丹丹, 曹宏伟. CTA评估缺血性脑卒中合并T2DM患者颈动脉斑块特征与血Hcy、Cys-C、ApoA1及UA的相关性[J]. 影像科学与光化学, 2022, 40(5): 1226-1230.

JIN Zhaowei, MA Feilong, ZHANG Dandan, CAO Hongwei. Correlation between Carotid Plaque Characteristics and Serum Hcy, Cys-C, ApoA1 and UA in Patients with Ischemic Stroke Complicated with T2DM Assessed by CTA[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1226-1230.

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