妊娠高血压患者的VOCAL参数和Hcy水平变化

doi:10.7517/issn.1674-0475.220516

影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (5): 1019-1023.DOI: 10.7517/issn.1674-0475.220516

妊娠高血压患者的VOCAL参数和Hcy水平变化

王玲玲¹, 郭志国², 卢丽敏³, 李爽¹, 任春丽⁴, 曹秀艳⁵, 谢守军¹, 郑华川⁶

1. 承德医学院附属医院检验科, 河北承德 067000;
2. 围场县妇幼保健院普外科, 河北承德 068450;
3. 承德医学院附属医院超声科, 河北承德 067000;
4. 承德医学院附属医院产科, 河北承德 067000;
5. 双滦区人民医院检验科, 河北承德 067000;
6. 承德医学院附属医院中心实验室, 河北承德 067000

收稿日期:2022-05-27 发布日期:2022-09-13
通讯作者: 郑华川
基金资助:
承德市科学技术研究与发展计划项目（201804A016）

Changes of VOCAL Parameters and Hcy Levels in Patients with Gestational Hypertension

WANG Lingling¹, GUO Zhiguo², LU Limin³, LI Shuang¹, REN Chunli⁴, CAO Xiuyan⁵, XIE Shoujun¹, ZHENG Huachuan⁶

1. Department of Laboratory, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China;
2. Department of General Surgery, Weichang County Maternal and Child Health Hospital, Chengde 067450, Hebei, P. R. China;
3. Department of Ultrasound, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China;
4. Department of Obstetrics, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China;
5. Department of Laboratory, Shuangluan District People's Hospital, Chengde 067000, Hebei, P. R. China;
6. Central Laboratory, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China

Received:2022-05-27 Published:2022-09-13

摘要/Abstract

摘要： 本文探究妊娠高血压（PIH）患者虚拟器官的计算机辅助分析（VOCAL）参数和同型半胱氨酸（Hcy）水平变化。选取121例PIH患者作为研究组，另纳入同期92例正常孕妇作为对照组。两组均行VOCAL检查，并采用全自动生化分析仪检测Hcy表达。结果显示，研究组血管化指数（VI）、血流指数（FI）、血管化血流指数（VFI）均低于对照组，血清Hcy水平高于对照组，FI、VI、VFI与Hcy呈负相关，且FI、VI、VFI、Hcy联合诊断PIH的AUC优于单一诊断（P<0.05）；VOCAL参数低表达患者不良妊娠结局发生率高于高表达患者，Hcy高表达患者不良妊娠结局发生率高于低表达患者，且VOCAL参数、Hcy均是PIH患者不良妊娠结局影响因素（P<0.05）。可见PIH患者VOCAL参数、Hcy呈异常表达，对疾病诊断及治疗具有指导意义。

关键词: 妊娠高血压, 虚拟器官的计算机辅助分析, 同型半胱氨酸, 妊娠结局, 相关性

Abstract: This paper investigated the changes of computer-assisted analysis of virtual organs (VOCAL) parameters and homocysteine (Hcy) levels in patients with gestational hypertension (PIH). 121 patients with gestational hypertension (PIH) were selected as the study group, and another 92 normal pregnant women in the same period were included as the control group. Both the two groups underwent VOCAL examination, and detected the Hcy expression by fully automated biochemical analyzer. The results showed that vascularity index(VI),flow index(FI), and vascularization flow index(VFI)in the study group were all lower than those in the control group, serum Hcy levels were higher than in the control group. FI, VI, VFI were negatively correlated with Hcy, and the AUC of combined diagnosis of PIH with FI, VI, VFI, and Hcy was better than that of single diagnosis (P<0.05). The incidence of adverse pregnancy outcome was higher in patients with low expression of VOCAL parameters than in those with high expression. The incidence of adverse pregnancy outcomes was lower in patients with high expression of Hcy than in patients with low expression, and both VOCAL parameters and Hcy were both factors influencing adverse pregnancy outcomes in patients with PIH (P<0.05). It can be seen that patients with PIH have abnormal expression of VOCAL parameters and Hcy, which has guiding significance for the diagnosis and treatment of the disease.

Key words: pregnancy induced hypertension, computer-aided analysis of virtual organs, homocysteine, pregnancy outcome, correlation

王玲玲, 郭志国, 卢丽敏, 李爽, 任春丽, 曹秀艳, 谢守军, 郑华川. 妊娠高血压患者的VOCAL参数和Hcy水平变化[J]. 影像科学与光化学, 2022, 40(5): 1019-1023.

WANG Lingling, GUO Zhiguo, LU Limin, LI Shuang, REN Chunli, CAO Xiuyan, XIE Shoujun, ZHENG Huachuan. Changes of VOCAL Parameters and Hcy Levels in Patients with Gestational Hypertension[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1019-1023.

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妊娠高血压患者的VOCAL参数和Hcy水平变化

Changes of VOCAL Parameters and Hcy Levels in Patients with Gestational Hypertension

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