CTP全脑灌注成像参数与Hcy的相关性及对缺血性脑卒中的诊断

doi:10.7517/issn.1674-0475.220307

摘要/Abstract

摘要： 本文分析头颅CT检查（CTP）全脑灌注成像参数与同型半胱氨酸（Hcy）的相关性及对缺血性脑卒中的诊断价值。选取156例疑似缺血性脑卒中患者，将确诊为缺血性脑卒中的80例患者为研究组，非缺血性脑卒中的76例患者为对照组。患者均进行CTP全脑灌注成像检查，并采用酶联免疫吸附分析法（ELISA）检测Hcy表达水平。结果显示，与对照组相比，研究组脑血流量（CBF）、脑血容量（CBV）参数降低，平均通过时间（MTT）、到达峰值时间（TTP）参数升高（P<0.05）。与研究组轻度、中度患者相比，研究组重度患者CBF、CBV参数降低，MTT、TTP参数与Hcy表达水平升高（P<0.05）。与CBF、CBV、MTT、TTP单项诊断相比，四项联合对缺血性脑卒中的诊断价值较高，AUC为0.876（P<0.05）。CTP全脑灌注成像在缺血性脑卒中患者的诊断中应用价值较高，且与患者的Hcy指标相关，可用于对缺血性脑卒中的诊断中。

关键词: CTP全脑灌注成像, 同型半胱氨酸, 缺血性脑卒中

Abstract: This paper investigated the correlation between cerebral perfusion imaging parameters of CTP and homocysteine (Hcy) and its diagnostic value in ischemic stroke. 156 patients with suspected ischemic stroke were selected, 80 patients with confirmed ischemic stroke were selected as the study group, and 76 patients with non-ischemic stroke as the control group. All patients underwent CTP whole- cerebral perfusion imaging examination, and Hcy expression level was detected by enzyme-linked immunoassay (ELISA). The results showed that compared with the control group, the parameters of cerebral blood flow (CBF), cerebral blood volume (CBV) in the study group were decreased, while the parameters of mean transit time (MTT) and time to peak (TTP) were increased (P<0.05). In study group the CBF and CBV parameters were decreased, MTT, TTP parameters and Hcy expression levels were increased in severe patients compared with mild and moderate patients in the study group (P<0.05). Compared with the single diagnosis of CBF, CBV, MTT and TTP, the combined diagnosis of the four items had higher diagnostic value for ischemic stroke, the AUC was 0.876 (P<0.05). CTP whole-cerebral perfusion imaging has high application value in the diagnosis of ischemic stroke patients and is related to the Hcy index of patients, which can be used for the diagnosis of ischemic stroke.

Key words: CTP whole cerebral perfusion imaging, homocysteine, ischemic stroke

吴彬彬, 余永强. CTP全脑灌注成像参数与Hcy的相关性及对缺血性脑卒中的诊断[J]. 影像科学与光化学, 2022, 40(5): 1269-1273.

WU Binbin, YU Yongqiang. Correlation between CTP Whole-Cerebral Perfusion Imaging Parameters and Hcy and Its Diagnostic Value for Ischemic Stroke[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1269-1273.

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