超声造影在检测冠心病颈动脉斑块内新生血管中的作用及与血清Hcy的关系

doi:10.7517/issn.1674-0475.220725

摘要/Abstract

摘要： 本研究考察超声造影(CEUS)在检测冠心病颈动脉斑块内新生血管(IPN)中的作用及与血清同型半胱氨酸(Hcy)和血脂表达的关系。选择167例稳定型冠心病(CAD)伴颈动脉斑块(厚度≥1.5mm)的患者作为研究对象,通过CEUS检查IPN,并将患者分为IPN组(n=82)和非IPN组(n=85)。比较两组患者的基线资料、颈动脉超声特征、血脂代谢指标、血清Hcy水平,以及主要不良心血管事件(MACE)发生率和发生时间。结果显示,IPN组的斑块最大厚度高于非IPN组[(3.23±1.07)mmvs(2.85±0.87)mm,P＜0.05]。两组患者的TC、TG、HDL-C和LDL-C差异无统计学意义(P>0.05)。IPN组的血清Hcy水平高于非IPN组(P<0.05)。MACE的总发生率为7.19%(12/167)。患者MACE的Kaplan-Meier生存曲线显示,IPN组患者随访时的MACE发生时间早于非IPN组患者(P＜0.05)。本研究提示,IPN、斑块最大厚度和血清Hcy水平可能是冠心病患者不良心血管事件的预测因子。

关键词: 超声造影, 冠心病, 颈动脉斑块内新生血管, 同型半胱氨酸, 斑块最大厚度

Abstract: This study investigated the role of contrast-enhanced ultrasonography (CEUS) in the detection of carotid plaque neovascularization (IPN) in coronary artery disease and its relationship with the expression of serum homocysteine (Hcy) and blood lipids. A total of 167 patients with stable coronary heart disease (CAD) and carotid plaque (thickness ≥1.5 mm) were selected as the research subjects. IPN was examined by CEUS, and the patients were divided into IPN group (n=82) and non-IPN group (n=85). The baseline data, carotid ultrasound characteristics, blood lipid metabolism indexes, serum Hcy levels, and the incidence and occurrence time of major adverse cardiovascular events (MACE) were compared between the two groups. The results showed that the maximum plaque thickness in the IPN group was higher than that in the non-IPN group [(3.23±1.07) mm vs (2.85±0.87) mm,P＜0.05]. There was no significant difference in TC, TG, HDL-C and LDL-C between the two groups (P>0.05). The serum Hcy level in the IPN group was higher than that in the non-IPN group (P＜0.05). The overall incidence of MACE was 7.19% (12/167). The Kaplan-Meier survival curve of patients’ MACE showed that the occurrence time of MACE in patients with IPN was earlier than in non-IPN group at follow-up (P＜0.05). This study suggests that IPN, maximum plaque thickness and serum Hcy levels may be predictors of adverse cardiovascular events in patients with coronary heart disease.

Key words: contrast-enhanced ultrasound, coronary heart disease, carotid intraplaque neovascularization, homocysteine, maximum plaque thickness

孙翔, 谭杰. 超声造影在检测冠心病颈动脉斑块内新生血管中的作用及与血清Hcy的关系[J]. 影像科学与光化学, 2022, 40(6): 1402-1406.

SUN Xiang, TAN Jie. The Role of Contrast-enhanced Ultrasound in the Detection of Carotid Intraplaque Neovascularization in Coronary Heart Disease and Its Relationship with the Expression of Serum Hcy[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1402-1406.

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