甲状腺癌患者CEUS特征及参数变化研究

doi:10.7517/issn.1674-0475.220507

摘要/Abstract

摘要： 本研究探讨超声造影（CEUS）鉴别诊断甲状腺肿瘤的良恶性及判断甲状腺癌是否发生淋巴结转移、包膜侵犯的临床价值。选取68例确诊的甲状腺癌患者作为甲状腺癌组、70例甲状腺良性肿瘤患者作为对照组，两组患者均接受了超声及CEUS检查，对比分析两组患者的超声声像特征、CEUS特征及参数差异；根据甲状腺癌是否有包膜侵犯、发生淋巴结转移情况对甲状腺癌患者分层并对比分析其CEUS参数的差异。甲状腺癌组的边界欠清晰、纵横径比≥1的患者占比显著大于对照组（P<0.05）；甲状腺癌组的边界不清晰、增强方式不均匀、早期明显消退的患者占比显著大于对照组（P<0.05）；甲状腺癌组结节的峰值强度（PI）、达峰时间（TTP）、平均通过时间（MTT）值均显著低于对照组（P<0.05）；发生淋巴结转移的甲状腺癌患者PI、TTP、MTT值低于未发生淋巴结的患者（P<0.05）。CEUS特征参数及影像学特征在鉴别诊断甲状腺肿瘤的良恶性及判断甲状腺癌恶性程度方面均具有重要的价值。

关键词: 超声造影, 鉴别诊断, 甲状腺癌, 良恶性, 恶性程度

Abstract: This study investigated the clinical value of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of benign and malignant thyroid tumors, and judging whether thyroid cancer has lymph node metastasis and capsule invasion. 68 patients with confirmed thyroid cancer were selected as the thyroid cancer group and 70 patients with benign thyroid tumor as the control group. Both groups of patients underwent ultrasound and CEUS. The ultrasonic image characteristics, CEUS characteristics and parameter differences between the two groups were compared and analyzed. According to whether the thyroid cancer has envelope invasion and lymph node metastasis, the patients with thyroid cancer were stratified, and the differences of CEUS parameters were compared and analyzed. The proportion of patients with unclear boundary and aspect ratio ≥ 1 in thyroid cancer group was significantly higher than that in control group (P<0.05). The proportion of patients with unclear boundary, uneven enhancement mode and obvious early regression in thyroid cancer group was significantly higher than that in control group (P<0.05). The peak intensity (PI), time to peak (TTP) and mean transit time (MTT) of nodules in thyroid cancer group were significantly lower than those in control group (P<0.05). The PI, TTP and MTT values of thyroid cancer patients with lymph node metastasis were lower than those without lymph nodes (P<0.05). CEUS characteristic parameters and imaging features are of great value in differential diagnosis of benign and malignant thyroid tumors and in judging the degree of malignancy of thyroid cancer.

Key words: contrast-enhanced ultrasonography, differential diagnosis, thyroid cancer, benign and malignant, degree of malignancy

李梅, 郑绥丽, 刘楚, 黄月春. 甲状腺癌患者CEUS特征及参数变化研究[J]. 影像科学与光化学, 2022, 40(4): 773-777.

LI Mei, ZHENG Suili, LIU Chu, HUANG Yuechun. Study on CEUS Characteristics and Parameter Changes in Patients with Thyroid Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 773-777.

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