高频超声弹性成像联合Anti-TG、Anti-TPO诊断甲状腺结节良恶性的研究

doi:10.7517/issn.1674-0475.220525

摘要/Abstract

摘要： 分析高频超声弹性成像联合抗甲状腺球蛋白抗体（Anti-TG）、抗甲状腺过氧化酶（Anti-TPO）对良恶性甲状腺结节的诊断价值。选取55例疑似甲状腺结节患者作为研究对象，根据病理检查结果分为良性组（30例）和恶性组（25例）。采用全自动化学发光仪检测Anti-TG、Anti-TPO水平，采用Pearson相关性分析高频超声弹性成像与Anti-TG、Anti-TPO之间的相关性。与良性患者相比，恶性患者舒张期最低血流速度（D）、阻力指数（RI）、搏动指数（PI）升高（P<0.05）。与良性患者相比，恶性患者Anti-TG、Anti-TPO升高（P<0.05）。D、RI、PI参数与Anti-TG、Anti-TPO表达水平正相关。与D、RI、PI单项诊断相比，三项联合对恶性甲状腺结节的诊断价值较高（P<0.001）。高频超声弹性成像在良恶性甲状腺结节患者中具有较高诊断价值，且与患者的Anti-TG、Anti-TPO指标相关，可用于对良恶性甲状腺结节的诊断。

关键词: 良恶性甲状腺结节, 高频超声弹性成像, 抗甲状腺球蛋白抗体, 抗甲状腺过氧化酶, 诊断价值

Abstract: This study analyzed the diagnostic value of high-frequency ultrasound elastography combined with anti-thyroglobulin antibody (Anti-TG) and anti-thyroid peroxidase (Anti-TPO) in the diagnosis of benign and malignant thyroid nodules. 55 patients with suspected thyroid nodules were selected as the research objects. According to pathological examination results, they were divided into the benign group with 30 cases and a malignant group with 25 cases. The levels of Anti-TG and Anti-TPO were detected by automatic chemiluminescence analyzer, and the correlation between high-frequency ultrasound elastography and Anti-TG and Anti-TPO was analyzed by Pearson correlation. Compared with benign patients, malignant patients had higher diastolic blood flow velocity (D), resistance index (RI) and pulsatility index (PI) (P<0.05). Compared with benign patients, Anti-TG and Anti-TPO were increased in malignant patients (P<0.05). D, RI and PI parameters were positively correlated with the expression levels of Anti-TG and Anti-TPO. Compared with the single diagnosis of D, RI and PI, the combination of the three items has higher diagnostic value for malignant thyroid nodules (P<0.001). High-frequency ultrasound elastography has high diagnostic value in patients with benign and malignant thyroid nodules, and is correlated with the patient's Anti-TG and Anti-TPO indicators, which can be used for the diagnosis of benign and malignant thyroid nodules.

Key words: positive and malignant thyroid nodules, high-frequency ultrasound elastography, antithyroglobulin antibodies, anti alpha peroxidase antibodies, diagnostic value

齐艳涛, 刘会明, 李宏宇, 柴吉鑫, 张浏阳, 李波, 敖亚洲. 高频超声弹性成像联合Anti-TG、Anti-TPO诊断甲状腺结节良恶性的研究[J]. 影像科学与光化学, 2022, 40(5): 1308-1312.

QI Yantao, LIU Huiming, LI Hongyu, CHAI Jixin, ZHANG Liuyang, LI Bo, AO Yazhou. Study of High Frequency Ultrasound Elastography Combined with Anti-TG and Anti-TPO in the Diagnosis of Benign and Malignant Thyroid Nodules[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1308-1312.

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