超声心动图联合血清miR-26b-5p在诊断急性心肌梗死中的应用

doi:10.7517/issn.1674-0475.220321

摘要/Abstract

摘要： 探讨超声心动图联合血清微小核糖核酸-26b-5p （miR-26b-5p）在急性心肌梗死（AMI）诊断中的价值。选取115例AMI患者（观察组）和80例陈旧性心肌梗死患者（对照组），分析两组超声心动图参数及血清miR-26b-5p差异。观察组左室舒张末期内径（LVEDd）、左室收缩末期内径（LVEDs）、左室舒张末期容积（LVEDV）、室收缩末期容积（LVESV）、心肌做功指数（Tei）明显高于对照组（P<0.05），而左室射血分数（LVEF）、E/A、miR-26b-5p明显低于对照组（P<0.05）。冠脉不同狭窄程度患者的LVEF、血清miR-26b-5p水平比较，差异有统计学意义（P<0.05）。血清miR-26b-5p与Gensini评分呈负相关（r=－0.503，P<0.05）。超声心动图联合血清miR-26b-5p诊断AMI的灵敏性和阴性预测值明显高于超声心动图单独诊断（P<0.05）。随访结果显示，发生主要不良心血管事件（MACE）患者LVEDs、LVESV明显高于未发生MACE患者（P<0.05），LVEF、miR-26b-5p明显低于未发生MACE患者（P<0.05）。LVEDs、LVEF、miR-26b-5p及联合预测MACE发生的ROC曲线下面积分别为0.753、0.732、0.701和0.915，P<0.05。急性心肌梗死患者的血清miR-26b-5p水平降低，miR-26b-5p联合超声心动图参数在鉴别诊断AMI及预测MACE方面有较好的应用价值。

关键词: 超声心动图, 微小核糖核酸-26b-5p, 急性心肌梗死, 预后, 诊断价值

Abstract: This paper discussed the diagnostic value of echocardiography combined with serum microRNA-26b-5p (miR-26b-5p) in acute myocardial infarction (AMI). 115 patients with AMI (observation group) and 80 patients with old myocardial infarction were selected as the control group, the echocardiographic parameters and serum miR-26b-5p of the two groups were analyzed. The left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVEDs), left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV) and myocardial work index (Tei) in the observation group were higher than those in the control group (P<0.05), while the left ventricular ejection fraction (LVEF), E/A and miR-26b-5p were significantly lower than those in the control group (P<0.05). There were significant differences in LVEF and serum miR-26b-5p levels in patients with different degrees of coronary stenosis (P<0.05). The serum miR-26b-5p was negatively correlated with Gensini score (r=-0.503, P<0.05). The sensitivity and negative predictive value of echocardiography combined with serum miR-26b-5p in the diagnosis of AMI were significantly higher than that of echocardiography alone (P<0.05). Follow-up results showed that LVEDs and LVESV in patients with major adverse cardiovascular events (MACE) were significantly higher than those without MACE (P<0.05), and LVEF and miR-26b-5p were significantly lower than those without MACE (P<0.05). The areas under the ROC curve of LVEDs, LVEF, miR-26b-5p and combined prediction of MACE were 0.753, 0.732, 0.701 and 0.915, respectively, P<0.05. The serum level of miR-26b-5p is decreased in patients with acute myocardial infarction, miR-26b-5p combined with echocardiographic parameters has a good application value in differential diagnosis of AMI and prediction of MACE.

Key words: echocardiography, microRNA-26b-5p (miR-26b-5p), acute myocardial infarction, prognosis, diagnostic value

秦继周, 金艳, 罗朝军. 超声心动图联合血清miR-26b-5p在诊断急性心肌梗死中的应用[J]. 影像科学与光化学, 2022, 40(5): 1083-1087.

QIN Jizhou, JIN Yan, LUO Zhaojun. Application of Echocardiography Combined with Serum miR-26b-5p in the Diagnosis of Acute Myocardial Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1083-1087.

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