肿瘤细胞的原子力显微术成像及表征研究

doi:10.7517/j.issn.1674-0475.2016.03.233

摘要/Abstract

摘要：

本文简单介绍了原子力显微镜的发展史,以及原子力显微镜的工作原理、工作模式、活细胞在生理状态下的成像方式等,特别介绍了生物型原子力显微镜、高速原子力显微镜在生物学领域的研究及应用。原子力显微镜在扫描速度、扫描范围、扫描精度方面的不断改进将为肿瘤细胞学研究提供源源不断的动力。本文着重阐述了原子力显微术在肿瘤领域的研究进展,包括原子力显微镜在肿瘤细胞形貌学特性、硬度、粘弹性方面的研究现状,并对原子力显微镜在肿瘤诊断及抗肿瘤药物研发方面的应用前景进行了展望。

关键词: 原子力显微镜, 肿瘤, 形貌特性, 硬度, 粘弹性

Abstract:

This article describes the history of the development of an atomic force microscope and simply introduces the working principle, working mode of atomic force microscopy (AFM), imaging methods of living cells under physiological state, etc. A special presentation biotypes atomic force microscopy, high-speed atomic force microscope in biology research and application is given in the paper. AFM with improved scanning speed, scanning range and the scanning precision will provide a steady stream of power to cytology cancer research. This paper expounds the research progress in the field of atomic force microscopy in tumors, including atomic force microscopy in tumor cells, topography characteristics, stiffness, viscoelasticity. And we also prospected the application of the atomic force microscope in tumor diagnosis and anti-tumor drugs research.

Key words: AFM, tumor, morphology characteristics, stiffness, viscoelasticity

高警蔚, 韩东. 肿瘤细胞的原子力显微术成像及表征研究[J]. 影像科学与光化学, 2016, 34(3): 233-244.

GAO Jingwei, HAN Dong. Study of AFM Imaging and Characterization of Tumor Cells[J]. Imaging Science and Photochemistry, 2016, 34(3): 233-244.

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