乳腺癌患者中磁共振成像参数与E-cadherin和CA153的相关性

doi:10.7517/issn.1674-0475.220127

摘要/Abstract

摘要： 本研究探讨磁共振成像参数与上皮钙黏蛋白（E-cadherin）、癌抗原153（CA153）的相关性及对乳腺癌患者的诊断价值。选取113例确诊为乳腺癌的患者作为研究组，另选取同期75例体检健康的志愿者作为对照组。使用酶联免疫吸附法（ELISA）检测E-cadherin，采用LIAISON全自动化学发光免疫分析仪检测血清CA153。两组均进行磁共振成像检查，对比两组的磁共振成像参数容量转移常数（Ktrans）、速率常数（Kep）、血管外细胞外间隙容积比（Ve），分析Ktrans、Kep、Ve与E-cadherin、CA153的相关性及对乳腺癌患者的诊断价值。结果显示，乳腺癌患者E-cadherin水平降低，病情越严重E-cadherin水平越低；乳腺癌患者CA153水平升高，病情越严重CA153水平越高。E-cadherin与Ktrans、Kep、Ve呈负相关，CA153与Ktrans、Kep、Ve呈正相关（P<0.05）。Ktrans、Kep、Ve三项联合对乳腺癌患者的诊断价值较高（P<0.05）。磁共振成像对乳腺癌患者有较高的诊断价值，且乳腺癌患者血清中E-cadherin表达量较低、CA153表达量较高。

关键词: 磁共振成像, 上皮钙黏蛋白, 癌抗原153, 乳腺癌

Abstract: This study explored the correlation between magnetic resonance imaging (MRI) and epithelial cadherin (E-cadherin), cancer antigen 153 (CA153) and its diagnostic value in breast cancer patients. 113 patients diagnosed as breast cancer were selected as the study group, and another 75 healthy volunteers were selected as the control group. Detected E-cadherin by enzyme-linked immunosorbent assay (ELISA), and detected serum CA153 by liaison automatic chemiluminescence immunoanalyzer. The two groups were examined by magnetic resonance imaging. The volume transfer constant (Ktrans), the rate constant (Kep) and extravascular extracellular volume fraction (Ve) were compared between the two groups, and the correlation between them, and the diagnostic value of them were also analyzed. The results showed that the E-cadherin level of breast cancer patients was lower, the more serious the disease was, the lower the E-cadherin level was. The level of CA153 increased in breast cancer patients, the more serious the disease was, the higher the CA153 level was. E-cadherin was negatively correlated with Ktrans, Kep and Ve, and CA153 was positively correlated with Ktrans, Kep and Ve (P<0.05). Ktrans、Kep、Ve combination had higher diagnostic value for breast cancer patients (P<0.05). MRI has a high diagnostic value for breast cancer patients, and the expression level of E-cadherin in breast cancer patients is low and the expression level of CA153 is high.

Key words: nuclear magnetic resonance, epithelial cadherin, cancer antigen 153, breast cancer

李佳鹂, 单航声, 张亚运, 宋宁林. 乳腺癌患者中磁共振成像参数与E-cadherin和CA153的相关性[J]. 影像科学与光化学, 2022, 40(4): 932-936.

LI Jiali, SHAN Hangsheng, ZHANG Yayun, SONG Ninglin. Correlation of MRI Parameters with E-cadherin and CA153 in Breast Cancer Patients[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(4): 932-936.

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