SMI评价颈动脉斑块中IPN形成及发生ACI的危险因素分析

doi:10.7517/issn.1674-0475.220401

摘要/Abstract

摘要： 本研究探讨超微血管成像（SMI）在评价颈动脉粥样硬化斑块中新生血管（IPN）形成及预测患者发生急性脑梗死（ACI）的价值。选取60例伴颈动脉粥样硬化斑块形成的ACI患者为ACI组、60例未发生ACI的颈动脉斑块患者为对照组。两组患者均接受SMI、超声血管造影（CEUS）检查，分别对比两组患者SMI、CEUS检测的颈动脉斑块内部新生血管分级情况，并采用多因素Logistic模型分析斑块内部IPN形成与发生ACI的关系。60例ACI患者中共检出120枚颈动脉斑块，SMI与CEUS诊断颈动脉斑块内部IPN形成的一致性检验值Kappa值为0.723，P=0.000；对照组共检出127枚颈动脉斑块，SMI与CEUS诊断颈动脉斑块内部IPN形成的一致性Kappa值为0.537，P=0.000；血清TG、LDL-C升高、合并糖尿病、合并高血压、颈动脉斑块内IPN形成是患者发生ACI的独立危险因素（P<0.05）。SMI在评价颈动脉粥样硬化斑块IPN形成与CEUS方式具有高度的一致性，且颈动脉斑块IPN形成与患者发生ACI具有高度的相关性。

关键词: 超微血流成像, 颈动脉粥样硬化斑块, 新生血管, 预测, 急性脑梗死

Abstract: This study investigated the value of ultramicroscopic flow imaging (SMI) in evaluating the formation of neovascularization (IPN) in carotid atherosclerotic plaques and in predicting the occurrence of acute cerebral infarction (ACI). 60 patients with ACI with carotid atherosclerotic plaque were set as the ACI group and 60 patients with carotid plaque without ACI set as the control group. Both of the two groups underwent SMI, ultrasound angiography (CEUS) examination, and compared the grading of neovascularization in the carotid plaque detected by SMI and CEUS in the two groups, and the multivariate Logistic model was used to analyze the relationship between the formation of IPN in the plaque and the occurrence of ACI. A total of 120 carotid plaques were detected in 60 ACI patients. The consistency test value of SMI and CEUS in diagnosing IPN formation in carotid plaques was Kappa=0.723, P=0.000. A total of 127 carotid plaques were detected in the control group, and the concordance Kappa value of SMI and CEUS in diagnosing IPN formation in carotid plaques was 0.537, P=0.000. The serum TG, LDL-C elevation, concomitant diabetes mellitus, concomitant hypertension, and IPN formation in carotid plaques were the independent risk factors for ACI patients (P<0.05). SMI is highly consistent with CEUS in evaluating carotid atherosclerotic plaque IPN formation, and carotid plaque IPN formation is highly correlated with the occurrence of ACI in patients.

Key words: ultramicroscopic blood flow imaging, carotid atherosclerotic plaque, neovascularization, prediction, Acute cerebral infarct

王文峰, 常叶, 牟荣骥. SMI评价颈动脉斑块中IPN形成及发生ACI的危险因素分析[J]. 影像科学与光化学, 2022, 40(5): 1299-1303.

WANG Wenfeng, CHANG Ye, MOU Rongji. SMI Evaluation of IPN Formation and Risk Factors for ACI in Carotid Plaques[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 1299-1303.

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