Correlation between MR Diffusion Kurtosis Imaging Parameters and Serum miR-181c, miR-210 Levels in Patients with Acute Cerebral Infarction

doi:10.7517/issn.1674-0475.201205

Abstract

Abstract: The purpose of this study was to investigate the correlation and significance of diffusion kurtosis imaging (DKI) parameters and serum microRNA (miR)-181c, miR-120 levels in patients with acute cerebral infarction. A total of 155 patients with acute cerebral infarction were selected as observation group and 100 healthy people were selected as control group. The levels of serum miR-181c and miR-210 in the two groups were detected, the MRI examination was performed in the observation group, mean kurtosis (MK), radial kurtosis (RK), axial kurtosis (AK), axial diffusion (AD) and mean diffusion (MD) and radial diffusion (RD) were analyzed. The experimental results showed that:The relative expression of miR-181c in the observation group was significantly higher than that in the control group (P<0.05), while the relative expression of miR-120 in the observation group was significantly lower than that in the control group (P<0.05). The MK, RK and AK in the lesion side of the observation group were significantly higher than those in the control side (P<0.05), while those of AD, MD and RD in the observation group were significantly lower than those in the control side (P<0.05). miR-181c was positively correlated with MK and RK (P<0.05), while miR-210 was negatively correlated with AK (P<0.05). Multiple linear regression analysis showed that the relative expression of miR-181c, miR-210, MK, RK, AK were the influencing factors of NIHSS score (P<0.05). This study confirmed that:In patients with acute cerebral infarction, MRI DKI parameters are positively correlated with serum miR-181c, negatively correlated with miR-210, and to some extent with the degree of nerve defect in patients.

Key words: acute cerebral infarction, magnetic resonance diffusion kurtosis imaging, miR-181c, miR-120, the correlation

ZHANG Yufeng, LIU Yanwu. Correlation between MR Diffusion Kurtosis Imaging Parameters and Serum miR-181c, miR-210 Levels in Patients with Acute Cerebral Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 754-759.

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