Correlation between CTPI Parameters, sdLDL-C, Annexin A2, Hcy and the Severity of Acute Cerebral Infarction and the Value of Evaluating the Intravenous Thrombolytic Effect of Alteplase

doi:10.7517/issn.1674-0475.210111

Abstract

Abstract: The purpose of this study is to investigate the relationship between CT perfusion imaging (CTPI) combined with small and dense low density lipoprotein cholesterol (sdLDL-C), Annexin A2, and homocysteine (Hcy) and the severity of acute cerebral infarction (ACI), and to evaluate the value of intravenous thrombolytic effect of alteplase. The results of the study found that CTPI parameters[cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), mean transit time (MTT)] were significantly correlated with the severity of ACI patients, as well as the serum sdLDL-C, Annexin A2 and Hcy levels (P<0.05). There was a significant correlation between CTPI parameters and serum sdLDL-C, Annexin A2, and Hcy (P<0.05). The AUC evaluated by CBV, CBF, MTT, TTP, sdLDL-C, Annexin A2, and Hcy at admission and after thrombolysis were all above 0.7, and they all had good evaluation performance, especially after thrombolysis, the AUC of the combined evaluation of thrombolytic effect was 0.929. These results can confirm that CTPI parameters, sdLDL-C, Annexin A2, Hcy are significantly related to the severity of ACI. The combination of various indicators after thrombolysis has high application value in evaluating the effect of thrombolysis, and can provide an important reference for clinical treatment plans.

Key words: acute cerebral infarction, head CT perfusion imaging, small and dense low density lipoprotein cholesterol, Annexin A2, homocysteine

XU Yan, GAO Yang. Correlation between CTPI Parameters, sdLDL-C, Annexin A2, Hcy and the Severity of Acute Cerebral Infarction and the Value of Evaluating the Intravenous Thrombolytic Effect of Alteplase[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 671-677.

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