IVUS in the Diagnosis of Coronary Atherosclerotic Plaque and Nutrient Vessels

doi:10.7517/issn.1674-0475.210518

Abstract

Abstract: This study was to investigate the value of intravascular ultrasound (IVUS) in the diagnosis of coronary atherosclerotic plaque and nourishing blood vessels. A total of 38 patients with acute coronary syndrome (ACS) and 52 patients with stable angina pectris (SAP) were selected. All patients were given IVUS examination. Meanwhile, serum lipoprotein associated phospholipase A2 (LP-PLA2) was detected by ELISA in patients with coronary heart disease. The vascular remodeling index, plaque eccentricity index, necrotic tissue area, the total incidence of vulnerable plaque and serum Lp-PLA2 in ACS group were significantly higher than those in SAP group (P<0.05), the calcified tissue area, fibrous tissue area and lipid/necrotic tissue area were significantly lower than SAP group (P<0.05). Serum Lp-PLA2 was positively correlated with IVUS parameters vascular remodeling index and lipid/necrotic tissue area. The number of nutrient vessels at the minimal lumen section, proximal section and distal section in ACS group were significantly more than those in SAP group (P<0.05). IVUS showed that the incidence of vulnerable plaque and the number of plaque nourishing vessels in ACS patients are significantly higher than those in SAP patients, some parameters of IVUS are correlated with serum Lp-PLA2.

Key words: intravascular ultrasound, plaque, nutrient vessels, acute coronary syndrome, stable angina pectoris

XI Jianfen, GUO Li, JIA Xiaojing. IVUS in the Diagnosis of Coronary Atherosclerotic Plaque and Nutrient Vessels[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(6): 883-887.

References

[1] 刘亚东, 王海晶, 王丽萍, 等. 脂蛋白相关磷脂酶A2、同型半胱氨酸和高密度脂蛋白胆固醇及D-二聚体检测对冠状动脉易损斑块的预测价值[J]. 岭南心血管病杂志, 2020, 26(1):11-15.
[2] 刘泽森, 张朝义, 张婷玉, 等. 脂蛋白(a)水平对冠状动脉罪犯血管斑块的影响-基于OCT的研究[J]. 中国循证心血管医学杂志, 2019, 11(5):601-606.
[3] 王璇, 贾海波. 冠心病患者粥样硬化斑块特征及其与血清PAF、PDGF、LP-PLA2的关系[J]. 岭南心血管病杂志, 2019, 25(1):24-27.
[4] 朱银梅, 李海嵘. 超声颈动脉内中膜厚度与斑块诊断冠状动脉粥样硬化性心脏病的价值对比[J]. 中国现代医学杂志, 2020, 30(6):105-109.
[5] Kitahara S, Kataoka Y, Sugane H, et al. In vivo imaging of vulnerable plaque with intravascular modalities:Its advantages and limitations[J]. Cardiovascular Diagnosis and Therapy, 2020, 10(5):1461-1479.
[6] Cismaru G, Serban T, Tirpe A. Ultrasound methods in the evaluation of atherosclerosis:From pathophysiology to clinic[J]. Biomedicines, 2021, 9(4):418.
[7] Volkov S V, Mytsyk S A, Naumov S M, et al. Intravascular ultrasound-guided internal carotid artery stenting[J]. Angiologiia i Sosudistaia Khirurgiia=Angiology and Vascular Surgery, 2019, 25(4):41.
[8] Nikolaeva I E, Zagitov I G, Buzaev I V, et al. Current techniques of intravascular imaging and implantation of bioresorbable coronary vascular scaffolds (stents)[J]. Creative Surgery and Oncology, 2019, 9(2):95-99.
[9] Zakharov A S, Michurova M S, Terekhin S A, et al. Intravascular ultrasound with virtual histology in assessment of atherosclerotic plaque composition in patients with coronary artery disease and type 2 diabetes mellitus[J]. Terapevticheskii Arkhiv, 2019, 91(12):41-46.
[10] Knoka E, Trusinskis K, Mazule M, et al. Circulating plasma microRNA-126, microRNA-145, and microRNA-155 and their association with atherosclerotic plaque characteristics[J]. Journal of Clinical and Translational Research, 2020, 5(2):60-67.
[11] Stone G W, Maehara A, Ali Z A, et al. Percutaneous coronary intervention for vulnerable coronary atherosclerotic plaque[J]. Journal of the American College of Cardiology, 2020, 76(20):2289-2301.
[12] 龚晓璇, 应良红, 李江津, 等. 血管内超声联合单核细胞/高密度脂蛋白胆固醇比值对非左主干临界病变患者行经皮冠状动脉介入治疗预后的评估[J]. 中国介入心脏病学杂志, 2019, 27(1):45-51.
[13] 王骕, 董耀荣, 沈睿, 等. 颈动脉超声造影评价益气通络方治疗冠状动脉粥样硬化性心脏病合并颈动脉不稳定斑块的临床研究[J]. 中西医结合心脑血管病杂志, 2019, 17(10):1448-1452.
[14] 郑庆昆, 刘剑雄, 黄晓波. 应用血管内超声指导冠状动脉临界病变介入治疗[J]. 中国动脉硬化杂志, 2020, 28(9):58-62.
[15] 赵鹏, 张彦周, 李爱琴, 等. 冠心病病人血清CXCL4和CXCL12水平与冠状动脉粥样斑块稳定性的关系[J]. 中西医结合心脑血管病杂志, 2019, 17(20):3162-3164.